Hempseed (Cannabis sativa ) lipid fractions alleviate high-fat diet-induced fatty liver disease through regulation of inflammation and oxidative stress

Heliyon
Naveen KaushalEra Kulshreshtha

Abstract

Diet and lifestyle-induced dysregulated lipid metabolism have been implicated in fatty liver disease. Chronic redox modulation and hepatic inflammation are key pathological mediators and hallmarks of fatty liver disease associated liver steatosis and steatohepatitis. In this context, owing to the beneficial phytochemical properties such as optimal omega-6: omega-3 PUFA ratio of hempseed, we aimed to explore its potential anti-inflammatory and antioxidant properties against high-fat diet (HFD)-induced experimental model of fatty liver disease. The hempseed lipid fractions (HEMP) were prepared and their ameliorating effects on HFD induced morphological changes, lipid profiles, liver function markers (LFT), markers of oxidative stress and inflammation were studied. Results indicated that HEMP administration to hypercholesterolemic rats resolved the morphological, histopathological, and biochemical indicators of fatty liver diseases. Further, the mechanistic evidence revealed that these hepatoprotective effects of HEMP are mediated through inhibition of oxidative stress and inflammatory mediators such as Cox-2, hPGDS, mPGES, IL-4, TNF-α and sEH. In conclusion, current study suggests the plausible antioxidant and anti-inflammatory r...Continue Reading

References

Jun 1, 1966·The Biochemical Journal·E D Wills
Jan 1, 1994·Methods in Enzymology·R L LevineE Shacter
Jun 1, 1993·The Journal of Clinical Investigation·Y OharaD G Harrison
Apr 12, 2000·Neurotoxicology and Teratology·A S DriverW R Mundy
Nov 3, 2004·Journal of Hepatology·Paolo SorrentinoRoberto Lobello
Apr 11, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Janardan K Reddy, M Sambasiva Rao
May 19, 2007·American Journal of Clinical Pathology·Melania MancoValerio Nobili
Dec 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ravindra RajakariarDerek W Gilroy
Apr 18, 2008·Canadian Journal of Physiology and Pharmacology·M A ProciukG N Pierce
May 20, 2008·Cellular and Molecular Life Sciences : CMLS·A F Hofmann, L R Hagey
Dec 2, 2009·Nutrition & Metabolism·Xueying ChenXian-Cheng Jiang
May 25, 2010·Journal of Hepatology·Vlad RatziuGiulio Marchesini
Feb 5, 2011·Nature Reviews. Gastroenterology & Hepatology·Tom Luedde, Robert F Schwabe
Nov 1, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Ziwei XuJieshou Li
Mar 1, 2012·World Journal of Gastroenterology : WJG·Vincent BraunersreutherFabrizio Montecucco
Mar 7, 2012·The Proceedings of the Nutrition Society·Lawrence N BarreraNigel J Belshaw
Jun 9, 2015·World Journal of Hepatology·Licia PolimeniFrancesco Angelico
Sep 4, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Carlos J Pirola, Silvia Sookoian
May 21, 2016·Journal of the American College of Cardiology·Paul D ThompsonBeth Taylor
Jul 28, 2016·Antioxidants & Redox Signaling·Schohraya SpahisEmile Levy
Jun 28, 2017·World Journal of Hepatology·Mark Benedict, Xuchen Zhang
Nov 2, 2017·American Journal of Physiology. Endocrinology and Metabolism·Emelie M GårdebjerKaren M Moritz
Mar 30, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Amedeo LonardoAyako Suzuki
Nov 2, 2019·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Naveen KaushalParminder Kaur

❮ Previous
Next ❯

Methods Mentioned

BETA
Enzyme-Linked Immunosorbent Assay

Software Mentioned

GraphPad
GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nutrition & Metabolism
D Rodriguez-Leyva, Grant N Pierce
Comprehensive Reviews in Food Science and Food Safety
Qingling Wang, Youling L Xiong
The Australasian Journal of Pharmacy
O S PRIEST
Cannabis and Cannabinoid Research
Pellegrino CerinoAlfonso Gallo
Genome Biology
Naomi Attar
© 2021 Meta ULC. All rights reserved