Henoch-Schönlein purpura in the third trimester of pregnancy

Biochemia Medica
Ivka DjakovicLiborija Lugović-Mihić

Abstract

Henoch-Schönlein purpura (HSP) is an IgA-mediated small vessels' vasculitis that affects the skin, intestines and kidneys. Pregnancy has been reported as an exacerbating factor. We present the case of a 24-year-old primigravida with HSP that occurred in the third trimester and lasted up to the end of the successful delivery. She had pruritic maculopapular exanthema on her legs. Biopsy of a cutaneous lesion was performed for histopathologic features and direct immunofluorescence (DIF) for the presence of perivascular IgA deposition. Histopathology of the cutaneous lesion confirmed leukocytoclastic vasculitis. A DIF examination of the skin lesion confirmed deposits of fibrinogen in the small blood vessel walls. Six weeks following delivery, the skin lesions almost completely disappeared. Control laboratory findings were normal. This case of HSP might have been primarily associated with a preceding respiratory infection but this should first be carefully investigated due to a possible severe immunological disease in the patient's background requiring special attention since nephrotic symptoms may occur.

References

Jul 16, 1999·Seminars in Arthritis and Rheumatism·C García-Porrúa, M A González-Gay
Feb 28, 2002·BMC Dermatology·Robert FeldmannFriedrich Breier
Aug 28, 2003·Clinical Nephrology·J RonkainenM Nuutinen
Dec 17, 2003·The British Journal of Dermatology·D L CumminsC H Nousari
Jan 14, 2004·The Journal of Obstetrics and Gynaecology Research·Minako KoizumiKimihiro Takechi
Feb 21, 2008·American Journal of Clinical Dermatology·Ko-Ron Chen, J Andrew Carlson
Jul 8, 2008·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·K KalmantisA Antsaklis
Sep 30, 2008·La Presse médicale·Christian Pagnoux
Dec 17, 2009·Clinical Reviews in Allergy & Immunology·Antonio BrucatoJill Buyon
Dec 17, 2009·European Journal of Pediatrics·Hugh J McCarthy, E Jane Tizard
Aug 7, 2012·Archives of Gynecology and Obstetrics·S TayabaliW Yoong
Oct 10, 2012·Arthritis and Rheumatism·J C JennetteR A Watts
Dec 25, 2013·Handbook of Clinical Neurology·Maxime D BérubéSylvain Lanthier
Jan 16, 2014·Autoimmunity Reviews·Yao-Hsu YangBor-Luen Chiang
Jun 24, 2014·International Journal of Rheumatic Diseases·Tarun Mittal, Manish Rathi
Aug 16, 2014·American Journal of Clinical Pathology·Allison R Larson, Scott R Granter
Nov 18, 2014·Rheumatic Diseases Clinics of North America·Robert G Micheletti, Victoria P Werth
May 27, 2015·Indian Dermatology Online Journal·Vijaya V MysorekarA L Shyam Prasad
Jul 22, 2015·European Journal of Pediatrics·Slimane AllaliMartin Chalumeau
Oct 28, 2015·ACG Case Reports Journal·Natalya IorioRon Schey
Nov 12, 2015·Current Opinion in Rheumatology·Kenan BarutOzgur Kasapcopur
Nov 28, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
Apr 15, 2016·Paediatrics and International Child Health·Ahmet Kağan ÖzkayaMehmet Davutoğlu

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Citations

Dec 28, 2018·Rheumatology·Johannes NossentDavid Preen

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Methods Mentioned

BETA
biopsy
enzyme-linked immunosorbent assay
ELISA
biopsies

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