Henry S. Kaplan Distinguished Scientist Award 2003. The crooked shall be made straight; dose-response relationships for carcinogenesis

International Journal of Radiation Biology
E J Hall

Abstract

Estimates of radiation-induced malignancies come principally from the atomic (A)-bomb survivors and show an excess incidence of carcinomas that is linearly related to dose from about 5 cGy to 2.5 Gy. Above and below this dose range there is considerable uncertainty about the shape of the dose-response relationship. Both the International Commission of Radiation Protected (ICRP) and the National Council of Radiation Protection (NCRP) suggest that cancer risks at doses lower than those at which direct epidemiological observations are possible should be obtained by a linear extrapolation from higher doses. The demonstrated bystander effect for irradiation exaggerates the consequences of small doses of radiation and implies that a linear extrapolation from high doses would underestimate low dose risks. It is possible to make estimates of the cancer risk of diagnostic radiological procedures. Helical computed tomography in children is of particular interest since it is rapidly increasing in use and the doses involved are close to the lower limit of significance in the A-bomb survivors. For example, an abdominal computed tomographic scan in a 1-year-old child can be estimated to result in a lifetime cancer risk of about 1:1000. In th...Continue Reading

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Citations

Jan 18, 2008·Physics in Medicine and Biology·Christina Zacharatou JarlskogHarald Paganetti
May 21, 2009·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Eric J Hall
Jun 10, 2008·Physics in Medicine and Biology·X George XuHarald Paganetti
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Sep 3, 2005·Radiation Research·Rainer K SachsPhilip Hahnfeldt
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Dec 21, 2011·Cancer Letters·Edouard I AzzamDebkumar Pain
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Mar 1, 2017·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Alexandru Dasu, Iuliana Toma-Dasu
Oct 4, 2006·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Keiji SuzukiMasami Watanabe
Jun 24, 2006·Journal of Pediatric Hematology/oncology·Kudret CağlarMünevver Büyükpamukçu
Oct 17, 2006·Radiation Medicine·Serdar SurenkokKaan Oysul
Feb 9, 2008·Pediatric Radiology·I-Chen TsaiTain Lee
Sep 9, 2005·Physics in Medicine and Biology·Hongyu JiangHarald Paganetti
Nov 28, 2013·European Radiology·Cristian Candela-JuanLuis Martí-Bonmatí
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Nov 26, 2020·The British Journal of Radiology·Claire TimlinUwe Schneider
Dec 13, 2006·International Journal of Radiation Oncology, Biology, Physics·Anthony M GriffinBrian O'Sullivan

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