Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells.

Brain Pathology
Paul O'CallaghanXiao Zhang

Abstract

Amyloid beta-peptide (Abeta) plaques, one of the major neuropathological lesions in Alzheimer's disease (AD), can be broadly subdivided into two morphological categories: neuritic and diffuse. Heparan sulfate (HS) and HS proteoglycans (HSPGs) are codeposits of multiple amyloidoses, including AD. Although HS has been considered a limiting factor in the initiation of amyloid deposition, the pathological implications of HS in Abeta deposits of AD remain unclear. In this study, immunohistochemistry combined with fluorescence and confocal microscopy was employed to gain deeper insight into the accumulation of HS with Abeta plaques in sporadic and familial AD. Here we demonstrate that HS preferentially accumulated around the Abeta40 dense cores of neuritic plaques, but was largely absent from diffuse Abeta42 plaques, suggesting that Abeta42 deposition may occur independently of HS. A codeposition pattern of HS with Abeta deposits in Tg2576 mice was also examined. We identified the membrane-bound HSPGs, glypican-1 (GPC1) and syndecan-3 (SDC3), in glial cells associated with Abeta deposits, proximal to sites of HS accumulation. In mouse primary glial cultures, we observed increased levels of GPC1 and SDC3 following Abeta stimulation. T...Continue Reading

References

Aug 4, 1995·The Journal of Biological Chemistry·R Gupta-BansalK R Brunden
Jan 1, 1997·Critical Reviews in Biochemistry and Molecular Biology·R Kisilevsky, P E Fraser
Jul 25, 1998·Archives of Neurology·M J McNamaraB T Hyman
Oct 21, 1999·The Biochemical Journal·K P SchofieldG David
Mar 15, 2000·The International Journal of Biochemistry & Cell Biology·S TumovaJ R Couchman
Jun 29, 2000·Annual Review of Biochemistry·M BernfieldM Zako
Mar 29, 2001·Physiological Reviews·D J Selkoe
May 31, 2001·Journal of Neuropathology and Experimental Neurology·A VerkkoniemiM Haltia
Jan 16, 2002·The Journal of Biological Chemistry·Michel A B A DennissenToin H van Kuppevelt
May 16, 2002·Neurobiology of Aging·Jack van HorssenMarcel M Verbeek
Jul 27, 2002·Annual Review of Cell and Developmental Biology·Wim Annaert, Bart De Strooper
Dec 14, 2002·The International Journal of Biochemistry & Cell Biology·Lars-Ake Fransson
Jul 25, 2003·Lancet Neurology·Jack van HorssenMarcel M Verbeek
Aug 30, 2003·Neuroscience Letters·Seita HaginoAkio Wanaka
Nov 7, 2003·Glia·Josep SauraJoan Serratosa
Jun 3, 2004·Neurobiology of Aging·Michael R D'AndreaMarch D Ard
Apr 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jin-Ping LiUlf Lindahl
Jul 14, 2005·Chemical Reviews·John M Whitelock, Renato V Iozzo
Aug 2, 2006·The Journal of Cell Biology·Johan KreugerUlf Lindahl

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Citations

Mar 23, 2011·Proceedings of the National Academy of Sciences of the United States of America·Fredrik NobornJin-Ping Li
Oct 15, 2009·The Journal of Biological Chemistry·Takahisa Kanekiyo, Guojun Bu
Aug 22, 2009·The Journal of Biological Chemistry·Michael P O'ConnellAshani T Weeraratna
Jul 29, 2009·Acta Neuropathologica·Ilona B BruinsmaMarcel M Verbeek
Nov 19, 2014·Molecular Neurobiology·Anne SuttkusThomas Arendt
Aug 27, 2014·BioMed Research International·Gan-lin ZhangJin-Ping Li
Jan 8, 2010·Glycobiology·Elina SandwallJin-Ping Li
Feb 26, 2013·Journal of Internal Medicine·U Lindahl, L Kjellén
Apr 8, 2017·Journal of Alzheimer's Disease : JAD·Beatriz GarcíaIván Fernández-Vega
Jul 30, 2019·Frontiers in Oncology·Sen WangBing Bai
Feb 17, 2021·ACS Chemical Biology·Peng WangXuefei Huang
Sep 12, 2018·Chemical Reviews·Nikos K KaramanosRenato V Iozzo

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