Heparan Sulfate Biosynthesis in Zebrafish.

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
Beata Filipek-GorniokLena Kjellén

Abstract

The biosynthesis of heparan sulfate (HS) proteoglycans occurs in the Golgi compartment of cells and will determine the sulfation pattern of HS chains, which in turn will have a large impact on the biological activity of the proteoglycans. Earlier studies in mice have demonstrated the importance of HS for embryonic development. In this review, the enzymes participating in zebrafish HS biosynthesis, along with a description of enzyme mutants available for functional studies, are presented. The consequences of the zebrafish genome duplication and maternal transcript contribution are briefly discussed as are the possibilities of CRISPR/Cas9 methodologies to use the zebrafish model system for studies of biosynthesis as well as proteoglycan biology.

References

Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·E QuentinH Kresse
Sep 17, 1998·The Journal of Biological Chemistry·U LindahlL Kjellén
Sep 25, 2003·Cell·María J García-García, Kathryn V Anderson
Jul 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Adam AmsterdamNancy Hopkins
Oct 21, 2005·Development·Dominique StickensZena Werb
Nov 1, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Adam B Cadwallader, H Joseph Yost
Nov 1, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Adam B Cadwallader, H Joseph Yost
Dec 30, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Adam B Cadwallader, H Joseph Yost
Apr 23, 2008·The Journal of Cell Biology·Jason J ZoellerRenato V Iozzo
May 20, 2008·The Journal of Biological Chemistry·Pernilla CarlssonLena Kjellén
Jul 26, 2008·PLoS Genetics·Aurélie ClémentHenry H Roehl
Apr 2, 2009·Biochemical and Biophysical Research Communications·Iwao TakahashiAkira Sugawara
Apr 25, 2009·Science·UNKNOWN Bovine Genome Sequencing and Analysis ConsortiumFeng-Qi Zhao
May 29, 2009·The Biochemical Journal·Toshiyasu KoikeHiroshi Kitagawa
Mar 17, 2010·Developmental Biology·B Frank EamesJohn H Postlethwait
Oct 29, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Bushra GorsiSally E Stringer
Feb 23, 2011·The Journal of Cell Biology·Fuchuan LiJorge Filmus
Jun 22, 2011·Cold Spring Harbor Perspectives in Biology·Stephane SarrazinJeffrey D Esko
Nov 4, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Svein O Kolset, Gunnar Pejler
Jan 19, 2012·PloS One·Malgorzata I WiwegerPancras C W Hogendoorn
Feb 22, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Sébastien Le JanJohan Kreuger
Oct 9, 2012·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Johan Kreuger, Lena Kjellén
Jun 19, 2013·Biochimica Et Biophysica Acta·Tadahisa Mikami, Hiroshi Kitagawa
Nov 29, 2013·Nucleic Acids Research·Judith A BlakeUNKNOWN Mouse Genome Database Group
Mar 4, 2014·American Journal of Human Genetics·Catherine BuiValérie Cormier-Daire
Oct 22, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jianzhong WenJack E Dixon
Feb 24, 2015·Matrix Biology : Journal of the International Society for Matrix Biology·Renato V Iozzo, Liliana Schaefer
Mar 15, 2015·PloS One·Beata Filipek-GórniokLena Kjellén
Jul 15, 2015·Nature·Andrea RossiDidier Y R Stainier
Jul 16, 2015·International Journal of Experimental Pathology·John Gallagher
Oct 22, 2015·Development·Fabienne E Poulain, H Joseph Yost
Feb 6, 2017·The Journal of Experimental Medicine·Stefano VolpiLuigi D Notarangelo
Oct 20, 2017·PLoS Genetics·Didier Y R StainierCecilia B Moens
Feb 20, 2018·Current Opinion in Structural Biology·Lena Kjellén, Ulf Lindahl

❮ Previous
Next ❯

Methods Mentioned

BETA
gene knockouts
targeted mutations
transgenic
gene knockdown
imaging techniques

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Biochemistry
Satomi Nadanaka, Hiroshi Kitagawa
The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
Johan Kreuger, Lena Kjellén
© 2021 Meta ULC. All rights reserved