Heparan sulfate potentiates the autocrine action of basic fibroblast growth factor in astrocytes: an in vivo and in vitro study

Neuroscience
F Gómez-PinillaC W Cotman

Abstract

Increasing evidence indicates that heparan sulfate proteoglycans have a critical role in the regulation of the activity of basic fibroblast growth factor by interacting with it or its receptor. In this study we examined the possibility that heparan sulfate can modulate the basic fibroblast growth factor system at a more fundamental level than activity regulation, by influencing the synthesis of basic fibroblast growth factor and its receptor messenger RNAs. Previous studies in vitro indicate that basic fibroblast growth factor promotes proliferation and differentiation of astrocytes. Accordingly, we examined the possibility that the action of heparan sulfate on the basic fibroblast growth factor system could have a critical role in the modulation of reactivity and/or proliferation of astrocytes in vitro and in vivo. We report that basic fibroblast growth factor applied to pure astrocyte cultures or rat neocortex promoted an increase in the messenger RNA for basic fibroblast growth factor itself and for its receptor. Furthermore, basic fibroblast growth factor applied directly into the brain elicited an increase in messenger RNA for the astrocytic marker glial fibrillary acidic protein. All of these actions, both in vitro and in...Continue Reading

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Citations

Apr 22, 2004·Neuroscience Research·Noriko HayashiKaeko Kamei
Dec 13, 2000·Brain Research Bulletin·F Gómez-PinillaE A Ryba
May 21, 1999·The European Journal of Neuroscience·C H ChauK F So
Aug 7, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Maria BodoPaolo Carinci
Aug 23, 2012·Clinical and Translational Allergy·Chrysanthi L SkevakiNikolaos G Papadopoulos
Feb 26, 2011·Journal of Tissue Engineering·Ye-Rang YunHae-Won Kim
Aug 2, 2011·Behavioural Brain Research·Farshad Nemati, Bryan Kolb
Jul 12, 2002·Journal of Neuroscience Research·Hong Hua LiFernando Gómez-Pinilla
Jun 24, 2005·Journal of Biomedical Materials Research. Part a·Toshie NagayasuKaeko Kamei
Jun 25, 2020·International Journal of Environmental Research and Public Health·Khidhir KamilJaya Kumar
Jul 13, 2004·Experimental Neurology·Maeve A CaldwellClive N Svendsen

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