Apr 1, 2004

Heparan sulfate proteoglycans: coordinators of multiple signaling pathways during chondrogenesis

Birth Defects Research. Part C, Embryo Today : Reviews
Catherine B Kirn-SafranD D Carson


Heparan sulfate proteoglycans are abundantly expressed in the pericellular matrix of both developing and mature cartilage. Increasing evidence indicates that the action of numerous chondroregulatory molecules depends on these proteoglycans. This review summarizes the current understanding of the interactions of heparan sulfate chains of cartilage proteoglycans with both soluble and nonsoluble ligands during the process of chondrogenesis. In addition, the consequences of mutating genes encoding heparan sulfate biosynthetic enzymes or heparan sulfate proteoglycan core proteins on cartilage development are discussed.

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Mentioned in this Paper

Biochemical Pathway
Enzymes, antithrombotic
Heparitin Sulfate
Enzymes for Treatment of Wounds and Ulcers
Enzymes, hematological
SDC2 gene

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