Heparan sulphate proteoglycan and wound healing in skin

The Journal of Pathology
J A McGrath, R A Eady

Abstract

Normal wound healing in skin embraces several reparative processes, many of which directly involve components of the extracellular matrix and the cutaneous basement membrane zone. Proteoglycans are a group of extracellular matrix macromolecules that have both structural and regulatory properties. In wound healing, certain proteoglycans fulfill a mechanical function of absorbing water and preventing tissue compression. However, proteoglycans may also have other roles in wound healing including a direct influence on inflammation, cell attachment and migration, and growth factor binding. Furthermore, proteoglycans may help to determine other aspects of the long-term quality of wound healing in skin through regulation of basement membrane permeability, epidermal hyperproliferation, and dermal fibrosis.

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Citations

Dec 15, 2010·International Journal of Vascular Medicine·Antonella TufanoGiovanni Di Minno
Oct 27, 2006·Expert Review of Medical Devices·Charles F BellowsW Scott Helton
Jun 4, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Chunmei ChengYasuhiko Yamamoto
Feb 9, 2000·Folia Microbiologica·P RossmannA Lodererová
Aug 24, 2002·Journal of Wound Care·P Stephens, D W Thomas
Jan 29, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Eyal ZchariaRinat Abramovitch

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