Apr 27, 2007

Heparan sulphate proteoglycans fine-tune mammalian physiology

Nature
Joseph R BishopJeffrey D Esko

Abstract

Heparan sulphate proteoglycans reside on the plasma membrane of all animal cells studied so far and are a major component of extracellular matrices. Studies of model organisms and human diseases have demonstrated their importance in development and normal physiology. A recurrent theme is the electrostatic interaction of the heparan sulphate chains with protein ligands, which affects metabolism, transport, information transfer, support and regulation in all organ systems. The importance of these interactions is exemplified by phenotypic studies of mice and humans bearing mutations in the core proteins or the biosynthetic enzymes responsible for assembling the heparan sulphate chains.

  • References90
  • Citations531

Mentioned in this Paper

Metabolic Process, Cellular
Enzymes, antithrombotic
Proteoglycan
Extracellular Matrix
Heparitin Sulfate
Metabolic Pathway
Enzymes for Treatment of Wounds and Ulcers
Body System
Enzymes, hematological
Anabolism

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