Heparanase and cyclooxygenase-2 gene and protein expressions during progression of oral epithelial dysplasia to carcinoma

Annals of Diagnostic Pathology
Hitoshi NagatsukaMotowo Nakajima

Abstract

Heparanase and cyclooxygenase-2 (COX-2) are 2 key enzymes that modulate diverse physiological processes during embryonic development and in adult life. Their deregulations have been implicated in the growth and progression of many cancer types. To date, comparatively little is known about the roles of these molecules during oral carcinogenesis. The aim of this study was to investigate the expression patterns of heparanase and COX-2 during progression of oral epithelial dysplasia (OED) to carcinoma. In situ hybridization and immunohistochemistry were performed on 5 cases of normal mucosa, 15 cases of OED, 5 cases of carcinoma in situ and/or microinvasive carcinoma, and 40 cases of oral squamous cell carcinoma (OSCC). Results demonstrated that heparanase and COX-2 messenger RNA and protein were absent in normal oral mucosa but were coexpressed in increasing intensity as OED progressed to OSCC. Concomitant heparanase- and COX-2-positive staining in the stromal cells suggests that OED/OSCC progression may be modulated by stromal-cancer cell interactions. Diffuse intense staining of poorly differentiated OSCC compared with staining localized to tumor nest periphery in well- and moderately differentiated OSCC suggests that heparanase...Continue Reading

References

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Feb 11, 2011·Cancer Metastasis Reviews·Gil ArvatzIsrael Vlodavsky

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Citations

Nov 30, 2013·Journal of Cellular and Molecular Medicine·Nir HirshorenMichael Elkin
May 13, 2015·Pathology Oncology Research : POR·Aditi Amit ByatnalMonica Charlotte Solomon
Jul 28, 2016·Journal of Cancer Research and Therapeutics·Jayendrakumar B PatelPrabhudas S Patel
Oct 8, 2017·Clinical Oral Investigations·Amanda Katarinny Goes GonzagaAna Miryam Costa de Medeiros
Dec 9, 2020·International Journal of Molecular Sciences·Ellen FrejborgAbdelhakim Salem

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