Heparanase is expressed in osteoblastic cells and stimulates bone formation and bone mass

Journal of Cellular Physiology
Vardit KramItai Bab

Abstract

Heparan sulfate proteoglycans (HSPGs) are ubiquitous macromolecules. In bone, they are associated with cell surfaces and the extracellular matrix (ECM). The heparan sulfate (HS) chains of HSPGs bind a multitude of bioactive molecules, thereby controlling normal and pathologic processes. The HS-degrading endoglycosidase, heparanase, has been implicated in processes such as inflammation, vascularization associated with wound healing and malignancies, and cancer metastasis. Here we show progressive mRNA expression of the hpa gene (encoding heparanase) in murine bone marrow stromal cells undergoing osteoblastic (bone forming) differentiation and in primary calvarial osteoblasts. Bone marrow stromal cells derived from transgenic mice expressing recombinant human heparanase (rh-heparanase) and MC3T3 E1 osteoblastic cells exposed to soluble rh-heparanase spontaneously undergo osteogenic differentiation. In addition, the transgenic bone marrow stromal cells degrade HS chains. In wild-type (WT) and hpa-transgenic (hpa-tg) mice, heparanase is weakly expressed throughout the bone marrow with a substantial increase in osteoblasts and osteocytes, especially in the hpa-tg mice. Heparanase expression was absent in osteoclasts. Micro-computed ...Continue Reading

References

Oct 1, 1992·Current Opinion in Cell Biology·T N WightE E Qwarnström
Jan 1, 1991·Annual Review of Biochemistry·L Kjellén, U Lindahl
Oct 1, 1990·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G S SteinT A Owen
Dec 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M ParfittR R Recker
Jan 1, 1987·Journal of Cellular Physiology·N SavionZ Nevo
Feb 1, 1986·Archives of Internal Medicine·A ZimranI Bab
Jan 1, 1996·The Journal of Cell Biology·A Erlebacher, R Derynck
Jul 21, 1998·The Journal of Biological Chemistry·D S PikasU Lindahl
Oct 6, 1998·Annual Review of Biochemistry·R V Iozzo
Jan 9, 1999·Matrix Biology : Journal of the International Society for Matrix Biology·G David, M Bernfield
Jun 17, 1999·Nature Medicine·J Harper, M Klagsbrun
Jul 15, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T HildebrandP Rüegsegger
Jul 16, 1999·Biochemical and Biophysical Research Communications·P H KussieP Bohlen
Jul 31, 1999·Experimental Hematology·G D Roodman
Aug 14, 1999·The Journal of Biological Chemistry·M Toyoshima, M Nakajima
Oct 9, 1999·The Journal of Biological Chemistry·M B FairbanksR L Heinrikson
Nov 5, 1999·Nature Genetics·E Arikawa-HirasawaY Yamada
Jun 29, 2000·Annual Review of Biochemistry·M BernfieldM Zako
Mar 16, 2001·Biochimica Et Biophysica Acta·C R ParishM D Hulett
Jun 28, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M ElkinI Vlodavsky
Aug 8, 2001·The Journal of Clinical Investigation·I Vlodavsky, Y Friedmann
Aug 8, 2001·The Journal of Clinical Investigation·J T Gallagher
Sep 8, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J M AlexanderM Rosenblatt
Mar 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Paul NewmanMartin J Shearer
Mar 5, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wei ZouZvi Bar-Shavit
Jul 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·John StreetEllen H Filvaroff
Sep 11, 2002·The Journal of Biological Chemistry·Wojciech J GrzesikNeal S Fedarko
Nov 21, 2002·Experimental Cell Research·Orit GoldshmidtBen Zion Katz
May 30, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Orit GoldshmidtIsrael Vlodavsky
Jul 3, 2003·The Journal of Biological Chemistry·Feng GongJin-ping Li
Aug 21, 2003·Biochemical and Biophysical Research Communications·Flonia Levy-AdamNeta Ilan
Nov 18, 2003·Histochemistry and Cell Biology·Masamichi SaijoSohei Kitazawa
Feb 11, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Eyal ZchariaIsrael Vlodavsky
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Norihiko SasakiTatsuro Irimura
Mar 27, 2004·The Journal of Biological Chemistry·Svetlana Gingis-VelitskiNeta Ilan
Apr 24, 2004·Critical Reviews in Eukaryotic Gene Expression·Jane B LianGary S Stein
May 6, 2004·Journal of Cell Science·Anna ZetserNeta Ilan

❮ Previous
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Citations

Aug 4, 2007·Journal of Molecular Histology·Victor NurcombeSimon M Cool
Aug 24, 2013·Journal of Photochemistry and Photobiology. B, Biology·Dilson SilvaSotiris Missailidis
Apr 15, 2011·The Journal of Clinical Investigation·Immanuel LernerMichael Elkin
Mar 20, 2013·BioMed Research International·Azumi HirataHiroaki Nakamura
Jul 25, 2009·Cellular and Molecular Life Sciences : CMLS·Catherine Kirn-SafranDaniel D Carson
Jan 26, 2016·Matrix Biology : Journal of the International Society for Matrix Biology·James MelroseMegan S Lord
Jun 18, 2010·Drug Discovery Today·Carmen Ruiz VelascoMarc Padrines
Jul 20, 2007·Journal of Cellular and Molecular Medicine·Veronique Vreys, Guido David
Aug 23, 2008·Journal of Cellular Physiology·Tatsuya MiyazakiOsamu Suzuki
Apr 5, 2011·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·John Whitelock, James Melrose
Mar 24, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Paul N SmithRachel W Li
Aug 12, 2006·The International Journal of Biochemistry & Cell Biology·Neta IlanIsrael Vlodavsky
Aug 4, 2015·BioMed Research International·Pawel OlczykKatarzyna Komosinska-Vassev
Dec 31, 2014·PloS One·Bruna Ribeiro CarneiroCarla Cristina Lopes
Jan 24, 2014·Acta ortopedica brasileira·Cintia Pereira de OliveiraMaria Aparecida da Silva Pinhal
Apr 27, 2007·Nature·Joseph R BishopJeffrey D Esko
Jul 11, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·François LamoureuxFrançoise Rédini
Jan 28, 2020·Journal of the Chinese Medical Association : JCMA·Po-Yu ChiuYa-Pei Chang
Jul 14, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Svetlana Gingis-VelitskiNeta Ilan
Mar 10, 2007·The Journal of Biological Chemistry·Yang YangRalph D Sanderson
Jul 10, 2013·Experimental and Therapeutic Medicine·Qinglin HanYoulang Zhou
Jun 4, 2017·Glycoconjugate Journal·Dulce Papy-Garcia, Patricia Albanese
Oct 5, 2017·Scientific Reports·Vardit KramMarian F Young
Sep 19, 2020·Journal of the Chinese Medical Association : JCMA·Yi-Jen ChenPeng-Hui Wang

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