Heparanase procoagulant activity, factor Xa, and plasminogen activator inhibitor 1 are increased in shift work female nurses

Annals of Hematology
Y NadirTamar Shochat

Abstract

Epidemiologic studies indicate on an increased risk of cardiovascular disease and cancer in shift workers, although the underlying mechanism is obscure. Heparanase directly enhances tissue factor (TF) activity leading to increased factor Xa production and subsequent activation of the coagulation system. In the present study, a comparison of coagulation markers among healthy shift working (SW) vs. healthy daytime working (DW) female nurses was performed. Thirty SW and 30 DW female nurses were enrolled. For each of the 60 participants, blood was drawn between 7:00 and 8:00 a.m. and at least 8 h after the last work shift. Plasma was studied for coagulation marker that included TF/heparanase procoagulant activity, TF activity, heparanase procoagulant activity, heparanase level, factor Xa level, plasminogen activator inhibitor 1 (PAI-1), plasminogen, α2-antiplasmin, fibrinogen, global protein C, von Willebrand factor, and D-dimer by chromogenic assays and enzyme-linked immunosorbent assays (ELISAs). Sleep quality was assessed by self-report according to the Pittsburgh Sleep Quality Index. The heparanase procoagulant activity increased by 2-fold and the TF/heparanase procoagulant activity increased by 1.5-fold in SW nurses compared t...Continue Reading

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Citations

Oct 23, 2015·Thrombosis and Haemostasis·Inna KoganY Nadir
Nov 10, 2017·European Journal of Haematology·Moshe MatanYona Nadir
Dec 13, 2019·American Journal of Industrial Medicine·Candice Y JohnsonJanet W Rich-Edwards
Jun 21, 2016·PloS One·Nataliya BohdanIrene Martínez-Martínez
Apr 2, 2021·Seminars in Thrombosis and Hemostasis·Yona Nadir

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