PMID: 9165476May 1, 1997Paper

Heparin-associated thrombocytopenia and thrombosis as the cause of a fatal thrombus on extracorporeal membrane oxygenation

Journal of Pediatric Surgery
T J ButlerK J Lancaster

Abstract

A rare state of acquired hypercoagulability known as heparin-associated or heparin-induced thrombocytopenia and thrombosis (HATT, HITT) exists. It appears to be caused by an antibody reaction with heparin-platelet factor 4 complexes. A mild and severe form exist, but both varieties occur after exposure to heparin. The authors describe a fatal neonatal case of hypercoagulability on extracorporeal membrane oxygenation, and their evaluation that determined the etiology as type II HATT. They discuss the pathophysiology of HATT as well as possible alternative anticoagulation approaches.

References

Jul 1, 1992·The Journal of Pediatrics·C PotterJ G McFarland
Dec 1, 1989·Annals of Internal Medicine·J N FrameM J Anderson
Dec 1, 1985·Chest·J E AnsellR R Beckner
May 1, 1993·Acta Paediatrica·I A MurdochD M Silver
Oct 1, 1995·Journal of Pediatric Surgery·J R Hocker, K L Saving

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Citations

Dec 6, 2003·The Journal of Pediatrics·Anne Friederike KlennerAndreas Greinacher
May 20, 2006·Thrombosis Research·Lorenz RischMarkus Schmugge
Jun 2, 2006·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Christian von HeymannClaudia Spies
Jul 31, 2004·Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual·Bahaaldin AlsoufiRoss Ungerleider
Dec 29, 2004·The Annals of Thoracic Surgery·Andreas BöningJochen T Cremer

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