Heparin-Binding Epidermal Growth Factor-Like Growth Factor as a Critical Mediator of Tissue Repair and Regeneration

The American Journal of Pathology
Duy T DaoDiane R Bielenberg

Abstract

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the EGF family. It contains an EGF-like domain as well as a heparin-binding domain that allows for interactions with heparin and cell-surface heparan sulfate. Soluble mature HB-EGF, a ligand of human epidermal growth factor receptors 1 and 4, is cleaved from the membrane-associated pro-HB-EGF by matrix metalloproteinase or a disintegrin and metalloproteinase in a process called ectodomain shedding. Signaling through human epidermal growth factor receptors 1 and 4 results in a variety of effects, including cellular proliferation, migration, adhesion, and differentiation. HB-EGF levels increase in response to different forms of injuries as well as stimuli, such as lysophosphatidic acid, retinoic acid, and 17β-estradiol. Because it is widely expressed in many organs, HB-EGF plays a critical role in tissue repair and regeneration throughout the body. It promotes cutaneous wound healing, hepatocyte proliferation after partial hepatectomy, intestinal anastomosis strength, alveolar regeneration after pneumonectomy, neurogenesis after ischemic injury, bladder wall thickening in response to urinary tract obstruction, and protection against ischemia/reperf...Continue Reading

References

Jan 14, 1994·Biochemical and Biophysical Research Communications·N ItoY Matsuzawa
Mar 18, 1996·Biochemical and Biophysical Research Communications·S KisoY Matsuzawa
Nov 14, 1998·The American Journal of Physiology·J M ParkC A Peters
Aug 13, 1999·The American Journal of Physiology·J M ParkM R Freeman
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·Y Yarden, M X Sliwkowski
Mar 8, 2002·The Journal of Burn Care & Rehabilitation·Randolph K CribbsGail E Besner
Mar 29, 2002·International Journal of Cancer. Journal International Du Cancer·Yoko MurayamaYuji Matsuzawa
Feb 26, 2003·Annals of Neurology·Kunlin JinDavid A Greenberg
Mar 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ryo IwamotoEisuke Mekada
Jul 29, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jianghuai LiuJudith Ann Foster
Sep 19, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Ahmad DaherDominique K Chopin
Nov 5, 2003·The Journal of Cell Biology·Daisuke NanbaShigeki Higashiyama
Feb 27, 2004·Investigative Ophthalmology & Visual Science·Ke-Ping XuFu-Shin X Yu
Apr 17, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kunlin JinDavid A Greenberg
Mar 12, 2005·American Journal of Physiology. Cell Physiology·Naoko Kanda, Shinichi Watanabe
Jun 1, 2005·Journal of Cell Science·Yuji ShirakataKoji Hashimoto
Aug 9, 2005·Seminars in Pediatric Surgery·Jiexiong FengGail E Besner
Sep 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sho TokumaruKoji Hashimoto
Nov 25, 2006·The Journal of Investigative Dermatology·Martina I OkwuezeLillian B Nanney

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Citations

Dec 24, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zhao-Ru DongTao Li
Aug 9, 2020·Nature Reviews. Gastroenterology & Hepatology·George K Michalopoulos, Bharat Bhushan
Feb 28, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chao HeChangsheng Zhao
Oct 13, 2020·Journal of Tissue Engineering and Regenerative Medicine·Nima ZakeriMehran Solati-Hashjin
Mar 27, 2021·Current Opinion in Nephrology and Hypertension·Raymond C Harris
Apr 26, 2021·Pediatric Research·Hanna DanielssonAnn Hellström
Jul 20, 2021·Endocrinology, Diabetes & Metabolism·Canjun ZhuQingyan Jiang

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