Heparin-Binding Protein as a Prognostic Biomarker of Sepsis and Disease Severity at the Emergency Department.

Shock
Fredrik KahnAdam Linder

Abstract

Rapid and early detection of patients at risk to develop sepsis remains demanding. Heparin-binding protein (HBP) has previously demonstrated good prognostic properties in detecting organ dysfunction among patients with suspected infections. This study aimed to evaluate the plasma levels of HBP as a prognostic biomarker for infection-induced organ dysfunction among patients seeking medical attention at the emergency department. Prospective, international multicenter, convenience sample study. Four general emergency departments at academic centers in Sweden, Switzerland, and Canada. All emergency encounters among adults where one of the following criteria were fulfilled: respiratory rate >25 breaths per minute; heart rate >120 beats per minute; altered mental status; systolic blood pressure <100 mm Hg; oxygen saturation <90% without oxygen; oxygen saturation <93% with oxygen; reported oxygen saturation <90%. None. A total of 524 emergency department patients were prospectively enrolled, of these 236 (45%) were eventually adjudicated to have a noninfectious disease. Three hundred forty-seven patients (66%) had or developed organ dysfunction within 72 h, 54 patients (10%) were admitted to an intensive care unit, and 23 patients (4%...Continue Reading

References

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Citations

Aug 1, 2019·Journal of Clinical Medicine·Lisa MellhammarFredrik Kahn
Jun 22, 2019·Annals of Intensive Care·Patrick M HonoreHerbert D Spapen
Jan 14, 2020·Journal of Immunology Research·Yang YangMingyi Zhao
Nov 15, 2019·Shock·Russell B HawkinsShawn D Larson
Jul 3, 2020·Cardiology Research and Practice·Yufeng CaiMingyi Zhao
Jan 31, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Maria SaridakiEvangelos J Giamarellos-Bourboulis

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