Heparin-binding protein measurement improves the prediction of myocardial injury-related cardiogenic shock.

BMC Cardiovascular Disorders
Tuo PanDong-Jin Wang

Abstract

Heparin-binding protein (HBP), a potent inducer of increased vascular permeability, is a potentially useful biomarker for predicting outcomes in patients with postoperative myocardial injury-related cardiogenic shock (MIRCS). We aimed to evaluate and validate HBP as a prognostic biomarker for postoperative MIRCS. We performed a case-control study in 792 patients undergoing cardiac surgery from January 1, 2016, to August 1, 2019, including 172 patients with postoperative MIRCS and 620 age- and sex-matched controls. The association between HBP and MIRCS was determined by multivariate logistic regression analysis. Receiver operating characteristic curves (ROCs) with area under the curve (AUC) were performed to calculate the cut-off value, sensitivity and specificity. The association between HBP and cardiac troponin T (cTnT) was determined by multivariable linear regression analysis. Blood samples were drawn from the coronary sinus and arterial line of the cardiopulmonary bypass (CPB) before aortic cross-clamping (time point 1) and 5 min after aortic declamping (time point 2). Before aortic cross-clamping, coronary sinus HBP (HBPCS1) showed no differences between the two groups. However, after declamping, the MIRCS group had a sign...Continue Reading

References

Jul 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·V RaoT E David
May 3, 2002·Journal of the American College of Cardiology·James L JanuzziElizabeth Lee-Lewandrowski
Jul 31, 2002·Circulation·Christophe AdrieJean-Marc Cavaillon
Sep 4, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Adam LinderPer Akesson
Oct 2, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Michael G GaiesJennifer C Hirsch
Feb 16, 2010·The Journal of Thoracic and Cardiovascular Surgery·Manjula MagantiVivek Rao
May 28, 2010·Journal of Innate Immunity·Adam LinderPer Akesson
Jan 5, 2011·Critical Care Medicine·Adam LinderBertil Christensson
Mar 14, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Charlott KjölvmarkAdam Linder
May 23, 2012·Critical Care : the Official Journal of the Critical Care Forum·Adam LinderJonas Sundén-Cullberg
Aug 9, 2016·Critical Care : the Official Journal of the Critical Care Forum·Giuseppe RistagnoUNKNOWN FINNRESUSCI Study Group
Nov 13, 2016·Journal of Critical Care·Ahmed T MokhtarJean-Francois Legare
Sep 25, 2017·The Annals of Thoracic Surgery·Eckhard MauermannGiovanna A L Lurati Buse
Nov 18, 2018·The Annals of Thoracic Surgery·Eero PesonenAlexey Schramko
Jul 6, 2019·Journal of Cardiothoracic Surgery·Min GeDong-Jin Wang

❮ Previous
Next ❯

Citations

Jan 18, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Niklas SternerIgor Zindovic

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
coronary artery bypass

Software Mentioned

SPSS
PASS

Related Concepts

Related Feeds

Cardiogenic Shock

Cardiogenic shock is a devastating consequence of acute myocardial infarction and is associated with an extremely high mortality. Here is the latest research.