Heparin biosynthesis

Handbook of Experimental Pharmacology
Pernilla Carlsson, Lena Kjellen

Abstract

Heparin and heparan sulfate share the same polysaccharide backbone structure but differ in sulfation degree and expression pattern. Whereas heparan sulfate is found in virtually all cells of the human body, heparin expression is restricted to mast cells, where it has a function in storage of granular components such as histamine and mast cell specific proteases. Although differing in charge and sulfation pattern, current knowledge indicates that the same pathway is used for synthesis of heparin and heparan sulfate, with a large number of different enzymes taking part in the process. At present, little is known about how the individual enzymes are coordinated and how biosynthesis is regulated. These questions are addressed in this chapter together with a review of the basic enzymatic steps involved in initiation, elongation, and modification of the polysaccharides.

Citations

Mar 13, 2014·Annual Review of Biochemistry·Ding Xu, Jeffrey D Esko
Mar 19, 2016·Journal of Thrombosis and Haemostasis : JTH·K ChandarajotiR Pawlinski
Dec 3, 2016·Glycoconjugate Journal·B MulloyC P Page
Nov 19, 2015·Carbohydrate Research·Karin ThorsheimUlf Ellervik
Apr 21, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Amélie I S SobczakAlan J Stewart
Dec 17, 2015·Pharmacological Reviews·Barbara MulloyClive P Page
Jul 9, 2016·The Journal of Biological Chemistry·Audrey DelignyLena Kjellén
Jan 29, 2014·Cytotechnology·Payel DattaSusan T Sharfstein
Sep 13, 2012·The Plant Journal : for Cell and Molecular Biology·Yan WangKenneth Keegstra
Apr 30, 2020·Computational and Structural Biotechnology Journal·Nehru Viji SankaranarayananUmesh R Desai
May 28, 2021·International Journal of Analytical Chemistry·Binjie LiMingjia Yu
Oct 4, 2017·Journal of Medicinal Chemistry·Li FuRobert J Linhardt
Oct 6, 2021·Mass Spectrometry Reviews·Andreas ZappeKevin Pagel
May 14, 2020·Molecular Neuropsychiatry·Lindsay M Melhuish BeaupreJames L Kennedy

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