Heparin bonding increases patency of long microvascular prostheses

Plastic and Reconstructive Surgery
E F RitterB Klitzman

Abstract

The high thrombogenicity of synthetic biomaterials has limited their use for reconstructive microsurgery. Prime factors in the thrombogenicity of synthetic materials in contact with blood include gas nuclei at the blood gas interface as well as the inherent thrombogenicity of the materials themselves. Expanded polytetrafluoroethylene (ePTFE) vascular prostheses were denucleated by placement in acetone and ethanol followed by degassed saline or by placement in degassed saline subjected to hydrostatic pressure. Heparinized grafts were prepared by coating with tridodecylmethylammonium chloride (TDMAC), followed by immersion in heparin. Grafts were installed to reconstruct the femoral artery (1 x 10 mm) or as renal-iliac bypasses (1 x 50 mm) in rats. In the femoral artery reconstruction model, control grafts thrombosed within 10 minutes of implantation. All acetone denucleated femoral grafts remained patent for 60 minutes but were occluded at day 1. All pressure denucleated femoral grafts remained patent for 60 minutes, whereas six were patent at 1 month. In contrast, 11 of 15 heparinized femoral grafts were patent at 1 month. In the renal iliac bypass model, all control grafts were thrombosed within 10 minutes, whereas all heparin...Continue Reading

References

Mar 1, 1977·Journal of Biomedical Materials Research·D LabarreM C Boffa
Mar 1, 1991·Journal of Biomedical Materials Research·C V BensenB Klitzman
Dec 1, 1988·Plastic and Reconstructive Surgery·C P DemasW J Barwick
Nov 1, 1985·Plastic and Reconstructive Surgery·D F BransonJ Desprez
Jan 1, 1972·Transactions - American Society for Artificial Internal Organs·G Schmer
Aug 1, 1982·American Journal of Surgery·P L ClausM P Kaye
Jun 1, 1980·Annals of Surgery·W H Edwards, J L Mulherin
May 1, 1980·Journal of Microsurgery·D H LidmanR K Daniel
Apr 1, 1993·Journal of Biomedical Materials Research·R D VannB Klitzman
Dec 6, 1963·Science·V L GOTTR C DUTTON
Jan 1, 1947·Physiological Reviews·H GOLDBLATT

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Citations

Jan 5, 2000·The Annals of Thoracic Surgery·D Shum-TimJ E Mayer
Jun 14, 2002·Medical Engineering & Physics·B S ConklinC Chen
Jun 7, 2011·Annual Review of Biomedical Engineering·Song Li, Jeffrey J D Henry
Oct 10, 2003·British Journal of Pharmacology·Joseph D Berglund, Zorina S Galis
Feb 24, 2001·British Journal of Plastic Surgery·H KatoS Torii
Jul 18, 2002·The Journal of Surgical Research·Jian-ming LiBruce S Cutler
Sep 16, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Settimio PacelliArghya Paul
Mar 22, 2002·Journal of Cardiovascular Pharmacology and Therapeutics·B M SasseenR L Wilensky
Aug 3, 2001·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·L B SunN Kitamura
Nov 17, 2005·The International Journal of Artificial Organs·L KarrerB H Walpoth

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