PMID: 8466349Apr 1, 1993Paper

Heparin-coated circuits reduce the inflammatory response to cardiopulmonary bypass

The Annals of Thoracic Surgery
Y J GuC R Wildevuur

Abstract

Cardiopulmonary bypass generates a systemic inflammatory response including the activation of the complement cascade and leukocytes contributing to postoperative morbidity. To evaluate whether the use of heparin-coated extracorporeal circuits could reduce these activation processes, we performed a study on 30 patients undergoing coronary artery bypass grafting who were randomly perfused with a heparin-coated circuit (Duraflo II, n = 15) or with a similar noncoated circuit (control, n = 15). Standardized systemic heparinization was applied for every patient before cardiopulmonary bypass. The use of heparin-coated circuits resulted in a reduction of systemic leukocyte activation during cardiopulmonary bypass reflected by reduced elastase release (p < 0.05) and tumor necrosis factor generation (p < 0.05) manifest after release of the aortic cross-clamp. In addition, blood samples taken from both the right and left atria after reperfusion revealed that the elastase release from the pulmonary microcirculation was absent in the Duraflo II group in contrast to the control group (p < 0.05). The pattern of complement activation, likely initiating this inflammatory reaction, was modified by heparin coating in two different aspects. There...Continue Reading

References

Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·D E Chenoweth, T E Hugli
Oct 1, 1992·The Annals of Thoracic Surgery·N J JansenC R Wildevuur
Apr 1, 1991·The Annals of Thoracic Surgery·Y J GuC R Wildevuur
Jul 1, 1991·The Annals of Thoracic Surgery·T E MollnesM Oppermann
Jan 1, 1990·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·L K von SegesserM Turina
Nov 8, 1985·Science·L J Old
Apr 1, 1985·Journal of Biomedical Materials Research·P W HeymanS W Kim
Dec 1, 1983·The Journal of Thoracic and Cardiovascular Surgery·J K KirklinA D Pacifico
Feb 26, 1981·The New England Journal of Medicine·D E ChenowethJ W Kirklin
Dec 6, 1963·Science·V L GOTTR C DUTTON

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Citations

Oct 1, 1996·Catheterization and Cardiovascular Diagnosis·I K De ScheerderJ H Piessens
Mar 10, 2001·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Y MisawaK Fuse
Feb 5, 2000·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·T OzawaY Takanashi
Dec 26, 2009·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Yosuke TakahashiShigefumi Suehiro
Sep 1, 1995·The Annals of Thoracic Surgery·B M SteinbergA C Galloway
Apr 26, 1996·International Journal of Cardiology·M Levy, A R Hartman
Jun 1, 1997·The Annals of Thoracic Surgery·H L LazarR J Shemin
Aug 6, 1998·The Annals of Thoracic Surgery·L A BrasilE Buffolo
Aug 6, 1998·The Annals of Thoracic Surgery·H H SchreursA J Bogers
Oct 13, 1998·The Annals of Thoracic Surgery·J P GottR A Guyton
Apr 10, 1999·The Annals of Thoracic Surgery·L M JacquetR A Dion
Oct 30, 1999·The Annals of Thoracic Surgery·H KumanoH Kinoshita
Dec 10, 1999·The Annals of Thoracic Surgery·S B HortonT R Karl
Mar 29, 2000·The Annals of Thoracic Surgery·T OzawaY Takanashi
Apr 6, 2000·The Annals of Thoracic Surgery·B M MatataM Galiñanes
Jan 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·R C GormanL H Edmunds
Mar 12, 1999·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·A ParolariP Biglioli
Jun 3, 1999·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·M SakaiT Itoh
Apr 1, 1997·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·I TigchelaarW van Oeveren
Feb 1, 1997·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·E FosseB Mohr
Aug 1, 1997·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·S BannanP Martin
May 1, 1997·Journal of Cardiothoracic and Vascular Anesthesia·D Royston
Aug 19, 2007·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Alexander R SantosRalph E Delius
Aug 31, 2002·Scandinavian Cardiovascular Journal : SCJ·S SvenmarkerT Aberg
Dec 1, 1996·The Annals of Thoracic Surgery·G JanvierJ F Hardy
Jun 13, 2015·Advances in Pharmacological Sciences·Sarah MousaviMaryam Motamedi
Feb 26, 2016·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Katsuhiro HosoyamaYoshikatsu Saiki
Mar 1, 1996·Acta Anaesthesiologica Scandinavica·H YamadaK Kurahashi
Oct 27, 1999·The Journal of Thoracic and Cardiovascular Surgery·P BorgdorffG J Tangelder

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