PMID: 3754062Jan 1, 1986Paper

Heparin cofactor II activity in plasma: application of an automated assay method to the study of a normal adult population

Scandinavian Journal of Haematology
T R AnderssonU Abildgaard

Abstract

A manual chromogenic substrate method for the determination of heparin cofactor II (HC II) activity in plasma has been adapted to the Cobas Bio centrifugal analyzer. By reducing the dermatan sulfate concentration used, interference by opacity was avoided, and the correlation between the manual and the new automated method was high (r = 0.96). Plasma samples from 182 females and 197 males were examined. The mean values of HC II activities in this normal population was relatively high, with a total range of 43-150% and a standard deviation of 17%. 4 apparently healthy individuals had levels below 60%. In males, the mean HC II activity was higher in the 50-59 yr age group than in either the 20-29 yr group or in the group above 60 yr (p less than 0.05). In females, the postmenopausal age group had higher mean HC II activities, but the difference was not statistically significant.

References

Oct 1, 1976·Scandinavian Journal of Haematology·O R OdegärdM Lie
Jun 1, 1976·Thrombosis Research·A N TeienM Höök
Dec 1, 1970·Scandinavian Journal of Clinical and Laboratory Investigation·U AbildgaardO Egeberg
Aug 1, 1984·Thrombosis Research·U Abildgaard, M L Larsen

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Citations

Jul 1, 1988·Acta paediatrica Scandinavica·T R AnderssonM L Larsen
Nov 14, 1997·The Journal of Biological Chemistry·J H HanD M Tollefsen
Jun 1, 1989·American Journal of Hematology·A ChuansumritW E Hathaway
Jan 1, 1989·Annals of the New York Academy of Sciences·C W PrattF C Church
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·J A Huntington
Nov 8, 2002·Archives of Pathology & Laboratory Medicine·Douglas M Tollefsen
Mar 1, 1992·Journal of Hepatology·H BellN Raknerud
Aug 1, 1988·Journal of Hepatology·T R Andersson, H Bell

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