PMID: 7083646Mar 1, 1982Paper

Heparin effect on blood viscosity

Clinical Cardiology
H A RuggieroE S Caprissi

Abstract

The effect of heparin on blood viscosity was investigated in a group of patients with acute myocardial infarction (AMI) and preinfarction angina (PA), whose blood viscosity was elevated. Viscosity was measured with Cannon, Fenske, and Routine viscometers. Kinematic viscosity, bath and whole blood, plasma, and serum viscosity were determined as well as dependent parameters (fibrinogen, serum proteins, number of platelets, and hematocrit). All of them were found to increase, and it was significantly proved that intravenous heparin immediately decreased plasma viscosity, but has a lesser effect on serum and whole blood viscosity. A dose of 1 cc = 50 mg = 5000 IU intravenous heparin, will maintain this decrease for a month. In our four-week-study, 1 cc i.v. heparin was administered at 6-hour intervals for the first 2 weeks, and 2 cc heparin subcutaneous injections were administered at 12-hour intervals for the next 2 weeks. We found that heparin also decreased fibrinogen, hematocrit, serum alpha 2 globulin, and number of platelets. Hyperviscosity, hypercoagulability, and the increase of platelet adhesiveness arae some of the most important physiopathological alterations of AMI and PA. The decrease of blood viscosity due to heparin ...Continue Reading

References

Sep 1, 1960·Circulation Research·F KELLOGG, J R GOODMAN
Jan 1, 1918·The Biochemical Journal·J W Trevan

Citations

Jun 20, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Giuseppe RegolistiEnrico Fiaccadori
Oct 31, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·George MetryNathan W Levin
May 1, 1983·Clinical Cardiology·H A RuggieroL H Ruggiero
Oct 1, 1987·Clinical Cardiology·H A RuggieroE S de Caprissi
Jan 15, 2005·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·L JivegårdP Ortenwall
Aug 9, 2016·Journal of Cardiothoracic Surgery·Shokoufeh CheheiliSobbiPeter Pickkers

Related Concepts

Angina Pectoris
Serum Proteins
Blood Viscosity
Gamma-Fibrinogen
Hematocrit Procedure
Liquaemin
Myocardial Infarction
Historical Events, 17th Century

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