Heparin fractions with high and low affinities to antithrombin III are cleared at different rates

Thrombosis Research
C CaranobeB Boneu

Abstract

The clearance characteristics of standard heparin (SH) and its fractions with high and low affinity to antithrombin III (HAH and LAH respectively) were studied by injecting 125I-labelled SH, HAH and LAH intravenously into the rabbits in increasing doses. Serial blood samples were then collected from an indwelling cannula for measurement of clearance, based both on radioactivity and anticoagulant activity. For equivalent weights injected, the radioactivity of HAH was cleared more slowly from the circulation than that of either SH or LAH. The radioactivity of SH, in turn, was cleared more slowly than that of LAH. The clearance of HAH, measured both by radioactivity and by anticoagulant activity were similar, whereas the clearance of the radioactivity of SH was more rapid than its anticoagulant activity (i.e. anti-factor Xa activity). These observations suggest that the radioactivity clearance curves of SH reflect a "net" estimation of the more complex clearance curves of the different heparin moieties whereas the anticoagulant clearance curves of SH reflects the clearance of the anticoagulant activity of a specific heparin fraction, in this case, the clearance of the anti-factor Xa activity of HAH. These differences suggest that ...Continue Reading

References

Jan 1, 1979·Thrombosis Research·J Dawes, D S Papper
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Citations

Sep 1, 1991·British Journal of Clinical Pharmacology·J DawesF Gianese
Aug 10, 2013·Experimental Hematology & Oncology·Kristian B Johansen, Torben Balchen
Dec 15, 1988·Thrombosis Research·M AndrewM R Buchanan
Jun 9, 2017·British Journal of Clinical Pharmacology·Jenneke LeentjensCornelis Kramers

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