PMID: 2489105Dec 1, 1989Paper

Heparin in molluscs: chemical, enzymatic degradation and 13C and 1H n.m.r. spectroscopical evidence for the maintenance of the structure through evolution

International Journal of Biological Macromolecules
C P DietrichA S Perlin

Abstract

The structural features and anticoagulant activity of heparins isolated from three species of molluscs (Anomalocardia brasiliana, Donnax striatus and Tivela mactroides) are reported. It is shown by chemical analyse, type of products formed by action of heparinase and heparitinase II, anticoagulant activity, 13C and 1H n.m.r. spectroscopy, that the mollusc heparins are virtually indistinguishable from heparins present in mammalian tissues. These data, taken as a whole, suggest that heparin has maintained its main structural features through evolution. The implications of these findings are discussed.

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Citations

Nov 9, 2010·Analytical and Bioanalytical Chemistry·Sean P ConcannonWesley E Workman
Jul 1, 1995·Comparative Biochemistry and Physiology. Part A, Physiology·J F PaivaC P Dietrich
Aug 23, 2011·Biochimica Et Biophysica Acta·Tarsis F GesteiraHelena B Nader
Jun 10, 2011·Communicative & Integrative Biology·Shuhei YamadaSuat Ozbek
Nov 28, 2013·Carbohydrate Polymers·Adriana S BritoSuely F Chavante
Jul 21, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·H B NaderC P Dietrich
Dec 13, 2005·Anais Da Academia Brasileira De Ciências·Barbara Mulloy
Feb 24, 2001·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·M DemirJ Fareed
Aug 5, 2017·Organic & Biomolecular Chemistry·Maria Cecília Zorél MeneghettiMarcelo A Lima
Oct 19, 2017·Critical Reviews in Food Science and Nutrition·Ling Chong WangHao Wu
Oct 24, 2013·Biological Chemistry·Vijayabaskar PandianSomasundaram T Somasundaran

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