Heparin-induced effects of prothrombin complex concentrates in thromboelastometry.

Wiener klinische Wochenschrift
Gisela ScharbertSibylle Kozek-Langenecker

Abstract

Prothrombin complex concentrates (PCC) are currently used to treat congenital or acquired coagulation factor deficiency. In case of serious bleeding caused by new oral anticoagulant agents, reversing treatment with PCC is under debate. PCC preparations mostly contain heparin to prevent thromboembolic events. In factor VIII and IX deficient plasma, Takeyama et al. observed in vitro a heparin effect at appropriate concentrations of PCCs. The aim of the present experiment was to investigate the heparin effect of four factor-PCC at clinically relevant concentrations in whole blood. In an in vitro experiment, we compared the PCC preparation used in the experiments of Takeyama with a high heparin content to a new heparin-free PCC preparation. After ethics committee approval and written informed consent, the citrated whole blood was obtained from ten healthy volunteers. We tested heparin-containing Prothromplex(®) and heparin-free Cofact(®) at concentrations of 0.31, 0.63, and 1.25 IU/ml. Protamine was added to another set of samples (1:1 heparin:protamine). We used the NATEM test in the rotational thromboelastometer ROTEM(®). In the heparin PCC preparation, we observed a significant (p < 0.001) concentration-dependent prolongation in...Continue Reading

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Citations

Feb 24, 2016·Scandinavian Journal of Clinical and Laboratory Investigation·Olof ElvstamUlf Schött
Feb 5, 2015·Biologicals : Journal of the International Association of Biological Standardization·Haijun CaoChangqing Li
Jan 24, 2014·British Journal of Haematology·Simon Davidson
Oct 31, 2015·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Martin PonschabHerbert Schöchl
Apr 7, 2020·European Journal of Anaesthesiology·Johannes GratzHerbert Schöchl
Dec 2, 2020·Journal of Clinical Medicine·Johannes GratzOliver Grottke

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