Heparin induced increase of t-PA antigen plasma levels in patients with unstable angina: no evidence for clinical benefit of heparinization during the initial phase of treatment

Thrombosis Research
K HuberB R Binder

Abstract

Patients with unstable coronary artery disease were randomly treated either with a combination therapy consisting of nitrates and calcium-channel blockers without or with addition of clinical grade heparin administered subcutaneously; in order to evaluate the effect of heparin treatment on the fibrinolytic system, tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) plasma levels were related to the clinical course of the disease. In heparinized patients thrombin time was prolonged more than 3-fold the normal range indicating effective heparin treatment. Heparinization led to a significant increase in t-PA antigen plasma levels (p less than 0.0001) within approximately four hours while PAI-1 activities remained unaltered. However, the measurable increase of the anticoagulant and pro-fibrinolytic activities of heparin did not result in a short-term benefit for the heparinized patients because the number of further ischemic attacks per patient during the observation period of three days was not different between the two study groups.

References

Jan 1, 1977·Haemostasis·F Markwardt, H P Klöcking
Oct 27, 1988·The New England Journal of Medicine·P ThérouxP deGuise
Feb 15, 1986·Thrombosis Research·C KorningerB R Binder
Mar 1, 1987·Thrombosis Research·H ArnesenP Kierulf
Oct 16, 1986·The New England Journal of Medicine·D J FitzgeraldG A FitzGerald
May 3, 1984·The New England Journal of Medicine·M J Davies, A Thomas
May 1, 1984·The American Journal of Cardiology·W GanzH J Swan
Apr 1, 1981·British Heart Journal·D R HolmesV Fuster

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Citations

Oct 1, 1990·British Journal of Haematology·N Marsh
Jun 17, 1998·Stroke; a Journal of Cerebral Circulation·V Gurewich, J N Liu
Jan 1, 1991·Journal of Population Economics·O S Mitchell
Jun 27, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kaj BlennowHenrik Zetterberg
Jun 1, 1993·The Journal of Primary Prevention·J KalafatM A Gara
Jun 28, 2014·The Cochrane Database of Systematic Reviews·Carlos A Andrade-CastellanosKirk Magee
Jul 19, 2001·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·L OlivottiC Brunelli
May 28, 2019·Journal of Thrombosis and Haemostasis : JTH·Bassem M MohammedDavid Gailani

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