Heparin inhibits the "quasi-lipoxygenase" activity of hemoglobin toward linoleic acid by oxidant scavenging

Prostaglandins, Leukotrienes, and Essential Fatty Acids
E P Brestel, M T Koes

Abstract

Previous studies have shown heparin to have antiinflammatory properties. We have attempted to determine if the mechanism involves the inhibition of lipid oxidation by utilizing a model system where linoleic acid is oxidized in the presence of oxygen and methemoglobin. Heparin inhibits this "quasi-lipoxygenase" activity prolonging the lag phase and slowing the rate of lipid peroxidation. An oxidant scavenging mechanism is also inferred from the fact that heparin is capable of inhibiting luminol-dependent chemiluminescence resulting from the reduction of 15-HPETE by methemoglobin. It is concluded that heparin, in at least this model system, is capable of inhibiting lipoxygenation by an oxidant scavenging mechanism.

References

Apr 1, 1979·Archives of Biochemistry and Biophysics·M E HemlerW E Lands
Jan 1, 1986·Journal of Free Radicals in Biology & Medicine·E P BrestelR A Cohen
Oct 23, 1974·Biochemical and Biophysical Research Communications·L J MarnettB Samuelsson
Nov 1, 1981·European Journal of Biochemistry·H KühnS M Rapoport
Oct 29, 1982·Biochemical and Biophysical Research Communications·A R MorrisonW A Brown

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Citations

Aug 1, 1994·Journal of Protein Chemistry·A L Kimzey, P N McFadden
Sep 1, 1992·The Journal of International Medical Research·E N Wardle

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