Heparin-like entities from marine organisms

Handbook of Experimental Pharmacology
S Colliec-JouaultC Delbarre-Ladrat

Abstract

Polysaccharides are ubiquitous in animals and plant cells where they play a significant role in a number of physiological situations e.g. hydration, mechanical properties of cell walls and ionic regulation. This review concentrates on heparin-like entities from marine procaryotes and eukaryotes. Carbohydrates from marine prokaryotes offer a significant structural chemodiversity with novel material and biological properties. Cyanobacteria are Gram-negative photosynthetic prokaryotes considered as a rich source of novel molecules, and marine bacteria are a rich source of polysaccharides with novel structures, which may be a good starting point from which to synthesise heparinoid molecules. For example, some sulphated polysaccharides have been isolated from gamma-proteobacteria such as Alteromonas and Pseudoalteromonas sp. In contrast to marine bacteria, all marine algae contain sulphated wall polysaccharides, whereas such polymers are not found in terrestrial plants. In their native form, or after chemical modifications, a range of polysaccharides isolated from marine organisms have been described that have anticoagulant, anti-thrombotic, anti-tumour, anti-proliferative, anti-viral or anti-inflammatory activities.In spite of the ...Continue Reading

Citations

Aug 29, 2013·ISRN Pharmacology·Clive Page
Mar 10, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dominique HeymannSylvia Colliec-Jouault
Nov 11, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cinzia Lanzi, Giuliana Cassinelli

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