PMID: 11920675Mar 29, 2002Paper

Heparin-like polymer improved healing of gastric and colic ulceration

Journal of Biomedical Materials Research
A MeddahiD Barritault

Abstract

A family of chemically substituted biopolymers has been developed to protect and stabilize heparin binding growth factors and was shown to enhance tissue repair in various in vivo models. One of these compounds, a dextran derivative named RGTA11, was tested for its ability to treat acute gastritis and colic ulceration models induced by ethanol and acid. RGTA was not efficient in reducing nor in protecting against gastric acidic secretion compared to EGF. Ethanol gastritis measured by the alteration score of the injured mucosa was reduced by 56% with the oral administration of RGTA at doses of 100 microg/kg (p < 0.01). A similar effect was obtained by PGE2 at a similar dose. Alterations of the colic mucosa were reduced after 72 h by 75% after oral administration of RGTA11. RGTA presents both anti-inflammatory and tissue repair activities mediated by growth factor protection. These two properties would be beneficial for digestive ulcer treatment. The results presented here provide evidence for these effects.

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Citations

Aug 21, 2013·Journal français d'ophtalmologie·F Brignole-BaudouinC Baudouin
Jan 15, 2005·Journal of Biomaterials Science. Polymer Edition·Laetitia FrankJacqueline Jozefonvicz
Mar 29, 2006·Annales pharmaceutiques françaises·D Barritault, J-P Caruelle
Mar 6, 2008·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Miao TongJohan W van Neck
Mar 21, 2006·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Ewa Kus, Andrzej Bienkiewicz
Jun 3, 2006·Journal of Biomedical Materials Research. Part a·Vincent RouetDenis Barritault
Jul 13, 2006·Journal of Biomedical Materials Research. Part a·C Lallam-LaroyeM-L Colombier
Jul 15, 2005·The Journal of Biological Chemistry·Vincent RouetJosé Courty

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