PMID: 11920660Mar 29, 2002Paper

Heparin-like polymers modulate proinflammatory cytokine production by lipopolysaccharide-stimulated human monocytes

Journal of Biomedical Materials Research
Sylvie Anastase-RavionDidier Letourneur

Abstract

The search for heparin-like materials remains an intensive field of research. In this context, we studied the immunomodulatory properties of semisynthetic dextran derivatives and naturally occurring sulfated polysaccharides present in brown seaweed (fucans). In this study, we investigated the functional potencies of fucan and dextran derivatives by analyzing their effects on the release of proinflammatory cytokines by resting or lipopolysaccharide (LPS)-stimulated human monocytes and their interactions on monocyte surfaces. The results showed that fucan, dextran derivatives, and heparin differentially (1) triggered interleukin-1alpha, tumor necrosis factor alpha, interleukin-6, and interleukin-8 production by monocytes in a dose-dependent manner, (2) modulated cytokine production by LPS-stimulated monocytes, and (3) specifically inhibited the binding of biotinylated LPS to monocyte membranes. Taken together, these data indicated that fucan and dextran derivatives displayed interesting immunomodulatory effects on human blood cells that could be relevant as new drugs or biomaterial coatings. Indeed, such polysaccharides, by regulating monocyte activation, could contribute to the improved biocompatibility of implants.

References

Jun 3, 1991·Journal of Immunological Methods·U Elsässer-BeileH Gallati
Apr 1, 1988·ASAIO Transactions·J M Anderson
Jun 1, 1995·Trends in Pharmacological Sciences·D J TyrellC P Page
Jan 1, 1995·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·K ItohH Takagi
Jul 1, 1994·Circulation Research·T L YueG Z Feuerstein
Sep 1, 1993·Cell Biology International·K SorimachiY Yasumura
Oct 1, 1995·Biomaterials·H ThomasM D Kazatchkine
Jul 1, 1996·British Journal of Haematology·J ManasterS Sela
Apr 1, 1996·The Pediatric Infectious Disease Journal·K D Yang, H R Hill
Jan 1, 1997·Journal of Biomedical Materials Research·M BenahmedG Daculsi
Aug 15, 1998·Transplant International : Official Journal of the European Society for Organ Transplantation·R SolbergA O Aasen
Feb 4, 1999·European Journal of Cell Biology·J L GirauxA M Fischer
May 26, 1999·Infectious Disease Clinics of North America·R R IngallsD Golenbock
Dec 22, 1999·Journal of Biomedical Materials Research·A U DanielsR A Smith
Aug 11, 2000·Kidney International. Supplement·V PanichiR Palla
Aug 11, 2000·Kidney International. Supplement·G PertosaF P Schena
Sep 28, 2000·Journal of Biomedical Materials Research·I M KhouwM J van Luyn
Mar 28, 2001·Carbohydrate Research·L ChevolotS Colliec-Jouault

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Citations

Oct 13, 2007·Biomacromolecules·Hironobu TakahashiDavid W Grainger
May 15, 2007·Transplantation·Caroline Fréguin-BouillandDidier Plissonnier
Mar 28, 2009·Journal of Biomaterials Science. Polymer Edition·Jean-François DeuxDidier Letourneur
Aug 7, 2013·Marine Drugs·Ivan Rui Lopes AlbuquerqueHugo Alexandre Oliveira Rocha
May 20, 2015·Marine Drugs·Maria Filomena de Jesus RaposoRui Manuel Santos Costa de Morais
Feb 22, 2012·The Journal of Surgical Research·Nicolas RouxDidier Plissonnier
Oct 16, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Jean-François DeuxDidier Letourneur

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