Heparin-Mimicking Sulfonated Polymer Nanoparticles via RAFT Polymerization-Induced Self-Assembly

Macromolecular Rapid Communications
Pratik GurnaniSébastien Perrier

Abstract

Heparin plays a significant role in wound healing and tissue regeneration applications, through stabilization of fibroblast growth factors (FGF). Risks associated with batch-to-batch variability and contamination from its biological sources have led to the development of synthetic, highly sulfonated polymers as promising heparin mimics. In this work, a systematic study of an aqueous polymerization-induced self-assembly (PISA) of styrene from poly(2-acrylamido-2-methylpropane sodium sulfonate) (P(AMPS)) macro reversible addition-fragmentation chain transfer (macro-RAFT) agents produced a variety of spherical heparin-mimicking nanoparticles, which were further characterized with light scattering and electron microscopy techniques. None of the nanoparticles tested showed toxicity against mammalian cells; however, significant hemolytic activity was observed. Nonetheless, the heparin-mimicking nanoparticles outperformed both heparin and linear P(AMPS) in cellular proliferation assays, suggesting increased bFGF stabilization efficiencies, possibly due to the high density of sulfonated moieties at the particle surface.

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Citations

Jan 19, 2019·Macromolecular Rapid Communications·Muriel Lansalot, Jutta Rieger
Jun 5, 2020·Biomacromolecules·Chanel C LaJayachandran N Kizhakkedathu
Jul 3, 2020·Journal of Colloid and Interface Science·Aaron M KingGemma-Louise Davies
Jan 31, 2019·Journal of the American Chemical Society·Yin NingSteven P Armes

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