PMID: 1206123Dec 1, 1975Paper

Heparin neutralizing activity test in the diagnosis of acute myocardial infarction

Journal of Clinical Pathology
J R O'BrienS V Lincoln

Abstract

We have previously shown in patients after recovery from a myocardial infarct (post-MI) that the heparin neutralizing activity (HNA) in the plasma is raised and that this activity may come from platelet factor 4 derived from activated platelets. This report concerns 89 patients admitted with acute chest pain; in 54, with evidence of acute infarction, the level of HNA is much higher than in a post-MI group or controls. Over the ensuing weeks the HNA decreases to the post-MI level. In 34 patients the evidence subsequently collected excluded a diagnosis of infarction; in these there were almost always normal amounts of HNA and little overlap with the results from the patients with infarcts. This easy test is therefore likely to prove clinically useful. Its significance is discussed. The platelet count and platelet volume are both abnormal in patients with acute infarction and also in the chest pain group so these tests do not help to discriminate.

Citations

Sep 1, 1978·British Journal of Haematology·J R O'Brien, M D Etherington
May 1, 1985·British Heart Journal·J W YarnellM D Etherington
Nov 1, 1979·Journal of Clinical Pathology·I A BakerJ R O'Brien
Jul 1, 1980·Thrombosis Research·J R O'BrienC M Adams
Jan 8, 1977·Lancet·K I BaghurstA S Truswell
Oct 1, 1978·Thrombosis Research·A H JensenR Masure
Jan 1, 1984·Clinical and Laboratory Haematology·J R O'BrienS Davison
Jan 1, 1980·Acta Medica Scandinavica. Supplementum·V RasiE Ikkala
May 28, 1977·Lancet·G B PorroM Fumagalli

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