Heparin regulates survival and differentiation of mesencephalic progenitors mediated via FGF2 in vitro

Neuroreport
Yanxin PeiZuoping Xie

Abstract

Heparin plays an important role in the survival and differentiation of mesencephalic progenitors mediated by FGF-2 in vitro. If the heparin concentration is gradually increased, cell survival mediated by FGF-2 can be greatly enhanced, to a maximum concentration of 20 ng/ml FGF-2 from 5 microg/ml heparin. However, differentiation of FGF-2 responsive mesencephalic progenitors is inhibited by heparin. When cortical, mesencephalic and hippocampal astrocytes were primed with FGF-2 and heparin, the latter two astrocytes promoted the differentiation of TH-positive neurons from mesencephalic progenitors. RT-PCR analysis showed that FGFR1, FGFR2 and FGFR3 were expressed in the cortical astrocytes, but only FGFR1 and FGFR3 were expressed in the mesencephalic and hippocampal astrocytes.

References

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Citations

Mar 4, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Zivar Salehi
Jun 24, 2005·Journal of Biomedical Materials Research. Part a·Toshie NagayasuKaeko Kamei

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