Abstract
Maternal lupus anticoagulants and anticardiolipin antibodies are associated with a syndrome of recurrent pregnancy loss or preterm birth in live-borns, fetal growth retardation, and placental infarction. Fourteen women with one or more abnormal pregnancy outcomes (total 28 losses, one severely growth-retarded premature live-born) and no normal outcomes were treated with full-dose, subcutaneous, twice-daily heparin therapy in subsequent pregnancies. Treatment was started at an estimated gestational age of 10.3 +/- 4.0 (mean +/- SD) weeks (range 6-18), in a mean total daily dosage of 24,700 +/- 7400 units (range 10,000-36,000). Fourteen of 15 pregnancies resulted in live births at 36.1 +/- 1.7 weeks (range 33-39). The mean birth weight percentile was 57 +/- 21 (range 10-90), and Apgar scores were good to excellent. The number of placental infarcts was fewer in treated cases than in previous deliveries. Five fetuses had third-trimester or perinatal problems with no sequelae, four discovered by close maternal-fetal monitoring. There was an increased rate of preterm and cesarean deliveries. Maternal complications of treatment were few and minor, with no hypertension, preeclampsia, or serious drug-related complications. Heparin appea...Continue Reading
Citations
Jun 1, 1994·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S KonidarisT Mantzavinos
Apr 1, 1995·Thrombosis Research·D A Triplett
Feb 26, 2000·Fertility and Sterility·R B StrickerE E Winger
Jun 9, 1998·Journal of Reproductive Immunology·D W Branch
Apr 20, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·D VinatierJ L Houpeau
Apr 1, 1990·Baillière's Clinical Rheumatology·D J Dudley, D W Branch
Jun 6, 2003·Best Practice & Research. Clinical Obstetrics & Gynaecology·Manjiri Khare, Catherine Nelson-Piercy
Oct 1, 1992·American Journal of Reproductive Immunology : AJRI·A ManyU Martinowitz
Apr 1, 1993·American Journal of Reproductive Immunology : AJRI·I KrauseY Shoenfeld
Mar 1, 1995·American Journal of Reproductive Immunology : AJRI·Y OzakiM Kunimatsu
Jan 1, 1995·American Journal of Reproductive Immunology : AJRI·L D ErmelW H Kutteh
Apr 1, 1996·American Journal of Reproductive Immunology : AJRI·W H Kutteh, L D Ermel
Apr 2, 1999·American Journal of Reproductive Immunology : AJRI·W H KuttehR Silver
Jan 14, 2005·Annals of the Rheumatic Diseases·D Le Thi ThuongJ-C Piette
Dec 1, 1992·Lupus·D A Isenberg