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Heparinase I acts on a synthetic heparin pentasaccharide corresponding to the antithrombin III binding site

Thrombosis Research

Jan 12, 2001

G YuR J Linhardt

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Abstract

A synthetic pentasaccharide, containing an intact antithrombin III (ATIII) binding site that is in clinical studies a specific antifactor Xa agent, serves as a substrate for a heparin lyase (heparinase I, EC 4.2.2.7) from Flavobacterium heparinum. Heparinase I, currently being assessed ...read more

Mentioned in this Paper

Antithrombin III, Human
Serine Proteinase Inhibitors, Exogenous
Lyase
Disaccharides
Liquaemin
Heparin Reversal Agent [EPC]
heparin pentasaccharide
Atenativ
Trisaccharides
Ligand Binding Domain
16
Paper Details
References
  • References15
  • Citations23
12
  • References15
  • Citations23
123

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Heparinase I acts on a synthetic heparin pentasaccharide corresponding to the antithrombin III binding site

Thrombosis Research

Jan 12, 2001

G YuR J Linhardt

PMID: 11152935

DOI: 10.1016/s0049-3848(00)00368-6

Abstract

A synthetic pentasaccharide, containing an intact antithrombin III (ATIII) binding site that is in clinical studies a specific antifactor Xa agent, serves as a substrate for a heparin lyase (heparinase I, EC 4.2.2.7) from Flavobacterium heparinum. Heparinase I, currently being assessed ...read more

Mentioned in this Paper

Antithrombin III, Human
Serine Proteinase Inhibitors, Exogenous
Lyase
Disaccharides
Liquaemin
Heparin Reversal Agent [EPC]
heparin pentasaccharide
Atenativ
Trisaccharides
Ligand Binding Domain
16

Feeds With Similar Papers

Biosynthetic Transformations

Biosyntheic transformtions are multi-step, enzyme-catalyzed processes where substrates are converted into more complex products in living organisms. Simple compounds are modified, converted into other compounds, or joined together to form macromolecules. Discover the latest research on biosynthetic transformations here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America

Cleavage of the antithrombin III binding site in heparin by heparinases and its implication in the generation of low molecular weight heparin

Proceedings of the National Academy of Sciences of the United States of AmericaSeptember 14, 2000
Z ShriverR Sasisekharan
Molecular and Biochemical Parasitology

Heparin can regulate the binding of Plasmodium falciparum circumsporozoite protein

Molecular and Biochemical ParasitologyJune 6, 2000
D Rathore, T F McCutchan
Paper Details
References
  • References15
  • Citations23
12
  • References15
  • Citations23
123

Download from

Publisher
PubMed
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