Heparinized nanohydroxyapatite/collagen granules for controlled release of vancomycin

Journal of Biomedical Materials Research. Part a
Catarina C CoelhoF J Monteiro

Abstract

The purpose of this study was to develop a bone substitute material capable of preventing or treating osteomyelitis through a sustainable release of vancomycin and simultaneously inducing bone regeneration. Porous heparinized nanohydroxyapatite (nanoHA)/collagen granules were characterized using scanning electron microscopy, micro-computed tomography and attenuated total reflectance Fourier transform infrared spectroscopy. After vancomycin adsorption onto the granules, its releasing profile was studied by UV molecular absorption spectroscopy. The heparinized granules presented a more sustainable release over time, in comparison with nonheparinized nanoHA and nanoHA/collagen granules. Vancomycin was released for 360 h and proved to be bioactive until 216 h. Staphylococcus aureus adhesion was higher on granules containing collagen, guiding the bacteria to the material with antibiotic, improving their eradication. Moreover, cytotoxicity of the released vancomycin was assessed using osteoblast cultures, and after 14 days of culture in the presence of vancomycin, cells were able to remain viable, increasing their metabolic activity and colonizing the granules, as observed by scanning electron microscopy and confocal laser scanning m...Continue Reading

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Citations

Jul 23, 2016·Therapeutic Delivery·Ts Sampath Kumar, K Madhumathi
Nov 7, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Satoru EgawaShinichi Sotome
Sep 26, 2019·Frontiers in Bioengineering and Biotechnology·Christiane Laranjo SalgadoFernando Jorge Mendes Monteiro
Oct 15, 2020·International Journal of Molecular Sciences·Stefanie EckesKatja Schmitz
Nov 11, 2021·Drug Delivery·Reem Khaled WassifSeham A Elkheshen

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