PMID: 9436582Jan 22, 1998Paper

Heparinoid anticoagulation and topical fibrin sealant in heparin-induced thrombocytopenia

The Annals of Thoracic Surgery
M R JacksonB M Alving

Abstract

The development of heparin-induced thrombocytopenia in patients who require systemic anticoagulation for cardiac and vascular operations poses a therapeutic dilemma because no alternative anticoagulants are generally available. Heparinoid (Org 10172) has been used as an alternative anticoagulant under protocol or on a compassionate use basis, and has recently been approved by the Food and Drug Administration. There is, however, no heparinoid antagonist to reverse the anticoagulation. This report describes the combined use of heparinoid anticoagulation and adjunctive fibrin sealant for topical hemostasis in a patient with heparin-induced thrombocytopenia. Recommendations for perioperative monitoring of heparinoid anticoagulation are provided.

References

Apr 1, 1993·The Journal of Pediatrics·F I Clark
Mar 1, 1996·The Annals of Thoracic Surgery·M J WilhelmH H Scheld

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Citations

May 17, 2000·Journal of Biomedical Materials Research·J J PriorF DeLustro
Sep 22, 2001·American Journal of Surgery·M R Jackson
Sep 22, 2001·American Journal of Surgery·M R Jackson
Nov 5, 1999·Current Opinion in Hematology·M R Jackson, B M Alving
Jan 25, 2012·The Annals of Thoracic Surgery·Lei YuJin Zhao
Apr 28, 2005·Expert Review of Cardiovascular Therapy·Peter A Kouides, William Fricke
Jun 27, 2012·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Daniele LodiBeniamino Palmieri

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