Hepatic 31 P-magnetic resonance spectroscopy identified the impact of melatonin-pretreated mitochondria in acute liver ischaemia-reperfusion injury.

Journal of Cellular and Molecular Medicine
Sheung-Fat KoHon-Kan Yip

Abstract

Acute liver ischaemia-reperfusion injury (IRI), commonly encountered during liver resection and transplantation surgery, is strongly associated with unfavourable clinical outcome. However, a prompt and accurate diagnosis and the treatment of this entity remain formidable challenges. This study tested the hypothesis that 31 P-magnetic resonance spectroscopy (31 P-MRS) findings could provide reliable living images to accurately identify the degree of acute liver IRI and melatonin-pretreated mitochondria was an innovative treatment for protecting the liver from IRI in rat. Adult male SD rats were categorized into group 1 (sham-operated control), group 2 (IRI only) and group 3 (IRI + melatonin [ie mitochondrial donor rat received intraperitoneal administration of melatonin] pretreated mitochondria [10 mg/per rat by portal vein]). By the end of study period at 72 hours, 31 P-MRS showed that, as compared with group 1, the hepatic levels of ATP and NADH were significantly lower in group 2 than in groups 1 and 3, and significantly lower in group 3 than in group 1. The liver protein expressions of mitochondrial-electron-transport-chain complexes and mitochondrial integrity exhibited an identical pattern to 31 P-MRS finding. The protein ...Continue Reading

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Citations

Feb 10, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rui ZhangChangwei Liu
Aug 27, 2021·Journal of Biochemical and Molecular Toxicology·Gokhan Burcin KubatSenay Akin

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Methods Mentioned

BETA
sedation
NMR
ELISA

Software Mentioned

ParaVision5
Labwork
Image Tool
SAS

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