Hepatic Abnormalities Are Present Before and Early After the Fontan Operation

The Annals of Thoracic Surgery
Matthew C SchwartzMeryl S Cohen

Abstract

Progressive hepatic fibrosis is common after the Fontan operation, but little is known about its onset. We sought to determine whether hepatic abnormalities before the Fontan operation, and whether further abnormalities can be identified soon afterward. Patients undergoing the Fontan operation at our institution were prospectively enrolled and underwent hepatic ultrasound with Doppler and serum testing immediately before and 3 to 6 months after the operation. Thirty patients were enrolled at a median age of 3.1 years (range, 2.2 to 8.1 years). Extracardiac Fontan was performed in 67%. Three patients (10%) had abnormal hepatic echotexture before the operation. At the post-Fontan study, mean liver length increased (9.9 versus 10.9 cm; p < 0.0001), and mean hepatic artery end-diastolic velocity decreased (18.8 versus 14.5 cm/s; p = 0.03). One patient showed new, abnormal hepatic echotexture after surgery. Mean aspartate aminotransferase (56.7 versus 60.7 U/L; p = 0.04), alanine transaminase (18.9 versus 33.9 U/L; p = 0.0002), and γ-glutamyl transferase (18.7 versus 46.1 U/L; p = 0.002) increased at the post-Fontan assessment compared with the preoperative values. By linear regression, hospital length of stay and duration with ches...Continue Reading

References

Jun 27, 2001·Scandinavian Journal of Gastroenterology·F PiscagliaL Bolondi
Sep 29, 2006·Heart·Christoph H KiesewetterGruschen R Veldtman
Mar 11, 2008·The Journal of Thoracic and Cardiovascular Surgery·Mireen Friedrich-RustHashim Abdul-Khaliq
May 16, 2008·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Govind B ChavhanOscar M Navarro
Jun 25, 2008·The Annals of Thoracic Surgery·Sonia CamposilvanLorenzo D'Antiga
Oct 1, 2011·The Journal of Thoracic and Cardiovascular Surgery·Matthew C SchwartzElizabeth B Rand
Oct 18, 2011·Pediatric Radiology·Maria José NoruegasConceição Sanches
Apr 25, 2012·Pediatric Radiology·Anat IlivitzkiAhuva Engel
Jun 15, 2012·Pediatric Cardiology·Matthew C SchwartzMeryl S Cohen
Oct 18, 2012·The Journal of Thoracic and Cardiovascular Surgery·Jennifer A JohnsonAnitha S John
Jul 16, 2013·International Journal of Cardiology·Robert W ElderWendy M Book
May 13, 2014·Pediatric Cardiology·William N EvansHumberto Restrepo
May 16, 2014·The Journal of Thoracic and Cardiovascular Surgery·Byung Won YooSeung Up Kim

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Citations

May 11, 2016·Pediatric Cardiology·William N EvansHumberto Restrepo
Dec 19, 2016·Clinical Transplantation·Benjamin A D'SouzaYuli Y Kim
Feb 1, 2017·Congenital Heart Disease·Moira B HilscherPatrick S Kamath
May 28, 2019·Expert Review of Gastroenterology & Hepatology·Haruki KomatsuTomoo Fujisawa
Aug 19, 2020·Pediatric Radiology·Jonathan R DillmanAdam M Lubert
Apr 7, 2018·Insights Into Imaging·Tae-Hyung KimTae Kyoung Kim
Dec 6, 2020·International Journal of Cardiology·Alejandro A BorquezHowaida G El-Said
Jan 25, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Danielle SgangaSharon Chen
Mar 9, 2021·World Journal for Pediatric & Congenital Heart Surgery·Jack Rychik, Elizabeth Goldmuntz

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