Hepatic and cardiac iron overload among patients with end-stage liver disease referred for liver transplantation

Clinical Transplantation
Avital Y O'GlasserJonathan M Schwartz

Abstract

Iron overload is associated with fatal cardiovascular events following liver transplantation. Myocardial iron deposits were observed post-mortem in patients who died of cardiac events after transplantation at our institution. This observation prompted testing to exclude cardiac iron in subsequent transplant candidates. To assess the results of testing for iron overload in liver transplant candidates at our institution. Ferritin, TIBC, and serum iron were measured in cirrhotics referred for transplantation. Patients with transferrin saturation ≥50% and ferritin ≥250 ng/mL underwent liver biopsy graded for iron. Patients with 3-4+ hepatic iron deposits underwent HFE mutation analysis and endomyocardial biopsy with iron staining. Eight hundred and fifty-six patients were evaluated for liver transplantation between January 1997 and March 2005. Two hundred and eighty-seven patients (34%) had transferrin saturation ≥50% and ferritin ≥250 ng/mL. Patients with markers of iron overload had more advanced liver disease than those with normal iron indices. One hundred and fifty-three patients underwent liver biopsy. Twenty-six patients (17%) had 3-4+ hepatic iron staining. One patient was a C282Y heterozygote. Endomyocardial biopsy was per...Continue Reading

References

Oct 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C MandelliD Conte
Aug 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F J FarrellE B Keeffe
Apr 1, 1996·Gastroenterology·C NiederauG Strohmeyer
Mar 1, 1997·Gastroenterology·J LudwigW P Baldus
Jul 1, 1995·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·K V KowdleyA S Tavill
Sep 9, 1999·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·B Y TungK V Kowdley
Feb 3, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D J BrandhagenM K Porayko
Mar 10, 2001·Clinics in Liver Disease·S SaabP Martin
May 9, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A S TavillUNKNOWN American Gastroenterological Association
Aug 18, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·D J Brandhagen
Jan 31, 2003·Gastroenterology·Bruce Y TungKris V Kowdley
Apr 16, 2003·Annals of Internal Medicine·Elizabeth D MorrisonKris V Kowdley
May 21, 2004·QJM : Monthly Journal of the Association of Physicians·J K Limdi, J R Crampton
Jun 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Darrell H G CrawfordElwyn E Elias
May 10, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Karen F MurrayUNKNOWN AASLD
May 25, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Sue C EngKris V Kowdley
Aug 9, 2005·Gastroenterology·Kris V KowdleyUNKNOWN National Hemochromatosis Transplant Registry
Jan 26, 2006·Alcoholism, Clinical and Experimental Research·Kimr BridleLinda M Fletcher
Aug 2, 2006·Annals of Internal Medicine·Evelyn P WhitlockPaula R Smith
Sep 19, 2006·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Miki NagashimaKensaku Dote
Oct 4, 2006·Annual Review of Physiology·Nancy C Andrews, Paul J Schmidt
Aug 8, 2007·Gastroenterology·Lei Yu, George N Ioannou
Aug 19, 2007·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·A W DemantC Reichel
Aug 29, 2007·Circulation·Farouc A JafferRalph Weissleder
Aug 31, 2007·World Journal of Gastroenterology : WJG·Giada Sebastiani, Ann-P Walker
Aug 31, 2007·World Journal of Gastroenterology : WJG·Yves Deugnier, Bruno Turlin
Sep 15, 2007·World Journal of Gastroenterology : WJG·Duygu Dee Harrison-Findik
Sep 22, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Antonello Pietrangelo
Sep 27, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Oyekoya T Ayonrinde, John K Olynyk
Dec 7, 2007·Lancet·Paul C Adams, James C Barton

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Citations

Nov 29, 2014·Case Reports in Transplantation·Rita JermynPaul J Gaglio
Jun 19, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Edouard Bardou-JacquetPierre Brissot
Sep 8, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tobias J WeismüllerChristian P Strassburg
Dec 11, 2019·Journal of Clinical Medicine·Yannis DimitroglouDimitris Tousoulis
Mar 5, 2020·Journal of Gastrointestinal Cancer·Ishaan VohraMelchor Demetria

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