PMID: 4022364Aug 1, 1985

Hepatic and encephalopathic components of Reye's syndrome: factor analysis of admission data from 209 patients

R A MitchellM L Ram


Factor analysis of admission data from 209 Reye's syndrome patients yielded three factors. Factor 1 was associated with encephalopathy, blood ammonia, creatinine kinase (CK), uric acid and, to a lesser extent, bilirubin. This factor was linked to the encephalopathy and hypermetabolic changes in muscle, possibly prostaglandin-mediated proteolysis. Factor 2 was associated with serum alanine aminotransferase (AlaAT) and aspartate aminotransferase (AspAT), and was identified as a hepatic lesion component. These factors correspond to two etiologic components of Reye's syndrome. Salicylate was only weakly associated with neuropathic and hypercatabolic indicators and not at all associated with the hepatic damage indicators.


Jan 1, 1999·Indian Journal of Clinical Biochemistry : IJCB·P L Wolf

Related Concepts

Brain Pathology
Psychogenic Coma
Liver Dysfunction
Upper Respiratory Infections
Reye-Like Syndrome
Salicylic Acids

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