Hepatic arterial infusion chemotherapy for metastatic colorectal cancer: a concise overview

Cancer Treatment Reviews
Fedricker D BarberRazelle Kurzrock

Abstract

Patients with colorectal cancer commonly succumb to the sequelae of hepatic metastases. Response to systemic therapy is inadequate. Hepatic arterial infusion (HAI) exposes liver metastases to high local concentrations of drug. Herein, we review the randomized trials of HAI in colorectal cancer. Data for this review were identified by searches of MEDLINE and references from relevant articles using the search terms "infusion intra-arterial" and "colorectal cancer." Abstracts and reports from meetings were included only when they related directly to previously published work. Only papers published in English between 1966 and 2003 were included. Randomized trials (5-fluorouracil- (5-FU-) or fluordeoxyuridine- (FUDR-) based regimens) often demonstrated superior response rates for HAI as compared to systemic chemotherapy (primary treatment or post-resection). Enhanced survival has, however, shown only when HAI was combined with systemic chemotherapy in the post-resection setting. For 5-FU-based and perhaps other regimens, randomized trials of combined regional and systemic therapy versus systemic treatment alone may be needed in order to determine whether or not there is a survival advantage after HAI in unresectable patients, as has...Continue Reading

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Citations

Jul 8, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Yoshiya FujimotoYoshihiro Moriya
Aug 1, 2005·Clinics in Colon and Rectal Surgery·Ketan R Sheth, Bryan M Clary
Sep 7, 2006·Annals of Surgical Oncology·David L BartlettAlan P Venook
Jul 18, 2008·Supportive Cancer Therapy·Michael A Morse
Dec 13, 2006·Seminars in Nuclear Medicine·Orazio SchillaciGiovanni Simonetti
Dec 20, 2005·Seminars in Oncology·Eric VibertRene Adam
Sep 29, 2011·Clinical Journal of Oncology Nursing·Brandi A BaroshRazelle Kurzrock
Dec 11, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Simone MocellinDonato Nitti
Apr 25, 2006·Journal of Clinical Gastroenterology·Waleed M AlazmiGlen L Lehman

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