Hepatic arterial infusion chemotherapy in the treatment of advanced hepatocellular carcinoma with portal vein thrombosis: a case-control study.

Clinical Radiology
A H K AbdelmaksoudR Lithy

Abstract

To study the treatment efficacy and survival of hepatic arterial infusion chemotherapy (HAIC) for patients with advanced hepatocellular carcinoma (HCC) and portal vein tumour thrombosis (PVTT) with compensated cirrhosis in comparison with sorafenib as the standard of care therapy versus best supportive care (BSC). This case-control study included 91 patients with advanced HCC and PVTT divided into three groups: Group 1 20 treated with HAIC, (50 mg adriamycin and 50 mg cisplatin were infused in hepatic artery); Group 2, 42 patients treated with BSC; and Group 3, 29 patients treated with sorafenib. Patients were followed up for assessment and comparison of treatment outcome by modified Response Evaluation Criteria in Solid Tumours (mRECIST) and survival. There was no significant difference among the groups studied regarding baseline demographic and tumour characteristics. The majority of patients who received sorafenib therapy (82.8%) had stable disease. The response rate (complete response + partial response) was significantly better in the HAIC group. HAIC patients had the longest survival compared with the best supportive care and sorafenib groups, which was statistically significant (29.2 ± 21.8, 4.55 ± 11.41, and 11.52 ± 8.7...Continue Reading

References

Apr 1, 1990·Controlled Clinical Trials·W D Dupont, W D Plummer
Nov 22, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GaneshanR Uberoi
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
Feb 23, 2010·Seminars in Liver Disease·Riccardo Lencioni, Josep M Llovet
Oct 22, 2010·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Agneta NorénUlf Haglund
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN American Association for the Study of Liver Diseases
Apr 3, 2015·World Journal of Gastroenterology : WJG·Matthew QuirkEdward Wolfgang Lee
Apr 9, 2015·World Journal of Gastroenterology : WJG·Myeong Jun Song
Jul 15, 2015·Clinical and Molecular Hepatology·Hyun Young Woo, Jeong Heo
Dec 18, 2015·Liver Cancer·M Kudo
Jan 9, 2018·Lancet·Alejandro FornerJordi Bruix
Aug 29, 2018·Journal of Gastrointestinal Oncology·Kei MoriyaHitoshi Yoshiji

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