Hepatic arterial infusion in the management of colorectal cancer liver metastasis: Current and future perspectives

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Nicolas ChapelleYann Touchefeu

Abstract

The technique of hepatic arterial infusion (HAI) for the treatment of liver metastases from colorectal cancer has been developed over more than 30 years. Although the indications and protocols for this technique have evolved with time, HAI is not routinely performed in clinical practice. Studies have been heterogeneous, with different regimens of intra-arterial drugs, associated or not with systemic chemotherapy, and with unconvincing outcomes. Technical difficulties for catheter placement have limited the implementation of this method in routine practice. The aim of this review is to present recent studies, highlighting technical improvements and promising combinations of oxaliplatin-based HAI with systemic treatments. HAI is being investigated in both the metastatic setting - in the first line and beyond - and in the adjuvant setting, and we will discuss its potential place in current and future patient management.

Citations

Nov 6, 2018·Cardiovascular and Interventional Radiology·Yasushi FukuokaKimihiko Kichikawa
Jul 25, 2020·The British Journal of Radiology·Thomas Helmberger
Mar 2, 2019·World Journal of Hepatology·Felix Che-Lok Chow, Kenneth Siu-Ho Chok
Jan 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kailong WangHaiyang Yu
Nov 18, 2020·World Journal of Clinical Oncology·Jack MartinEmmanuel Huguet

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