Hepatic arterial vasodilation is independent of portal hypertension in early stages of cirrhosis

PloS One
Miriam MoellerAlexander Zipprich

Abstract

The compensatory increase in hepatic arterial flow with a decrease in portal venous flow is known as the hepatic arterial buffer response. In cirrhosis with elevated portal pressure, the vascular resistance of the hepatic artery is decreased. Whether this lower resistance of the hepatic artery is a consequence of portal hypertension or not remains unknown. The aim of the study was to investigate the hepatic arterial resistance and response to vasoconstriction in cirrhosis without portal hypertension (normal portal resistance). Cirrhosis was induced by CCl4-inhalation for 8 weeks (8W, normal portal resistance) and for 12-14 weeks (12W, elevated portal resistance). Bivascular liver perfusion was performed at 8W or 12W and dose response curves of methoxamine were obtained in the presence or absence of LNMMA (nitric oxide synthase blocker). Vascular resistances of the hepatic artery (HAR), portal vein (PVR) and sinusoids (SVR) were measured. Western Blot (WB) and Immunohistochemistry (IHC) were done to measure eNOS and HIF 1a expression. HAR in both groups of cirrhotic animals (8W and 12W) were lower compared to controls. Dose response curves to methoxamine revealed lower HAR in both cirrhotic models (8W and 12W) regardless the mag...Continue Reading

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Citations

Apr 24, 2018·British Journal of Pharmacology·Barbara SchreierAlexander Zipprich
Feb 28, 2016·Digestive Diseases and Sciences·Bernardo Times de CarvalhoSimone Cristina Soares Brandão
May 18, 2016·World Journal of Gastroenterology : WJG·Emilio González-ReimersFrancisco Santolaria-Fernández
Jan 14, 2017·World Journal of Gastroenterology : WJG·Sebastian Mueller
Jan 14, 2017·World Journal of Hepatology·Dmitry Victorovich GarbuzenkoDmitry Vladimirovich Belov
Dec 10, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Alexander ZipprichCristina Ripoll
Feb 14, 2018·Journal of Agricultural and Food Chemistry·Tim BaldenspergerMarcus A Glomb

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