Hepatic arteriolosclerosis: a small-vessel complication of diabetes and hypertension

The American Journal of Surgical Pathology
Maya BalakrishnanDhanpat Jain

Abstract

Liver involvement in diabetes is well recognized in the form of steatohepatitis and glycogenic hepatopathy. More recently, sinusoidal fibrosis, even in the absence of steatosis, has also been suggested to be associated with diabetes (diabetic hepatosclerosis); however, case-control studies are lacking. In addition, microangiopathy (hyaline arteriolosclerosis), a well-known complication of diabetes, has not been well studied in liver. Therefore, we undertook a cross-sectional blinded study with the specific aim of evaluating the association between hepatic sinusoidal fibrosis and hepatic arteriolosclerosis (HA) with diabetes. Liver biopsy findings from 89 diabetic patients obtained between January 2006 and December 2009 were compared with those of 89 nondiabetic patients matched by age and hepatitis C virus infection status. Patients with cirrhosis, liver mass, right heart failure, significant alcohol use, or insufficient available clinical information were excluded. Medical records were reviewed for the presence of diabetes, body mass index, diabetes treatment, and comorbidities at the time of biopsy (eg, underlying liver disease, hypertension, dyslipidemia). Liver biopsies were evaluated blinded to all clinical data (including...Continue Reading

References

Dec 1, 1995·The American Journal of Surgical Pathology·K P Batts, J Ludwig
Jul 9, 2002·Best Practice & Research. Clinical Obstetrics & Gynaecology·George I Gorodeski
Feb 6, 2004·Gastroenterology·Hashem B El-SeragJames E Everhart
Oct 2, 2007·The American Journal of Medicine·Ingrid J Hickman, Graeme A Macdonald
Aug 12, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·John T BassettDong H Lee
Jan 15, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Guilan Chen, Elizabeth M Brunt
Sep 19, 2009·American Journal of Clinical Pathology·Rachel M HudackoBillie S Fyfe
Mar 3, 2010·Nature Reviews. Gastroenterology & Hepatology·Elizabeth M Brunt
Jun 27, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Yu-Cheng Lin, Chuan-Hong Kao

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Citations

Jul 14, 2016·Clinical Transplantation·Isabel Campos-VarelaNorah A Terrault
Aug 3, 2020·European Journal of Gastroenterology & Hepatology·Rita de Sousa Gameiro, Filipe G Nery
Mar 15, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Laure ElkriefRichard Moreau
Feb 26, 2019·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Theodora StratigouGeorge Ioannidis
May 4, 2021·Digestive Diseases and Sciences·Chau ToPaul J Thuluvath

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Methods Mentioned

BETA
biopsies
biopsy

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