PMID: 7537164Mar 1, 1995Paper

Hepatic artery dexamethasone infusion inhibits colorectal hepatic metastases: a regional antiangiogenic therapy

Annals of Surgical Oncology
Y ArisawaE R Sigurdson

Abstract

A randomized trial treating colorectal hepatic metastases demonstrated that hepatic arterial floxuridine (FUdR) with dexamethasone increased tumor response compared with hepatic arterial FUdR alone (Cancer 1992;69:327-34). The mechanism of this improvement is unclear. We investigated the effect of hepatic arterial dexamethasone with or without FUdR on the growth of colorectal hepatic metastases in an animal model. BD-IX rats were inoculated intrasplenically with 10(7) K12/TRb colon cancer cells on day 0. On day 14, the hepatic metastases were counted and hepatic arterial catheters placed for chemotherapy. Forty-eight animals were randomized to 4 groups for 14 days of infusion with heparinized saline alone (group A), heparinized saline with dexamethasone 0.03 mg/kg/d (group B), heparinized saline with FUdR 2 mg/kg/d (group C), or heparinized saline with dexamethasone 0.03 mg/kg/d plus FUdR 2 mg/kg/d (group D). The hepatic metastases were recounted by laparotomy on day 28. Response in each rat was expressed in terms of percentage change in number of hepatic nodules between the number of hepatic nodules seen on days 14 and 28. In vitro chemosensitivity of K12/TRb to dexamethasone with or without FUdR was examined using an MTT (3-(...Continue Reading

References

Jan 3, 1990·Journal of the National Cancer Institute·J Folkman
Jan 1, 1990·Cancer Chemotherapy and Pharmacology·K E LeeA T Cockett
Jun 1, 1984·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N KemenyN Geller

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Citations

Jul 28, 2012·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Bohuslav Melichar
Apr 1, 1996·The British Journal of Surgery·J N VautheyE M Copeland
Jul 28, 2011·NMR in Biomedicine·Chang Hee LeeRichard C Semelka
Nov 19, 2011·Journal of Magnetic Resonance Imaging : JMRI·Hyeon Tae JeongSang-Joon Shin
Jun 11, 1999·American Journal of Clinical Oncology·E PelosiA Mussa

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