Abstract
Hepatocellular carcinoma (HCC) is the fifth and seventh most common cause of cancer in men and women, respectively. Transcatheter arterial chemoembolization (TACE) is the standardized therapy for the intermediate stage of HCC. However, the 3-year overall survival remains low (<30 %) in these patients. Thus, there is a critical need for the development of treatment modalities to improve the survival rate. This study aimed to evaluate whether the combination of (131)I-metuximab with chemoembolization could improve treatment efficiency. Between January 2009 and January 2010, a prospective two-arm nonrandomized study was performed in patients with intermediate HCC. Of 138 patients, 68 (combination therapy group) received 132 courses of intraarterial (131)I-metuximab injections combined with chemoembolization (mean 1.94 per patient, median 2, range 1-2), followed by 152 sessions of TACE (mean 2.24 per patient, median 2, range 0-4). The remaining 70 patients (monotherapy group) received 296 sessions of TACE (mean 4.23 per patient, median 4, range 1-7). The overall median survival times for the combination therapy group and the group treated only with TACE were 26.7 months (95 % CI 20.7-31.3 months) and 20.6 months (95 % CI 15.3-24.7 ...Continue Reading
References
Jan 1, 1981·Cancer·A B MillerA Winkler
Aug 31, 2000·Radiology·S KatyalR L Baron
Oct 11, 2001·Journal of Hepatology·J BruixUNKNOWN EASL Panel of Experts on HCC
Jun 7, 2002·Lancet·Josep M LlovetUNKNOWN Barcelona Liver Cancer Group
Nov 30, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Zhao-Chong ZengGuo-Liang Jiang
Jan 24, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Josep M Llovet, Jordi Bruix
Apr 17, 2003·Current Topics in Developmental Biology·Bryan P Toole
Oct 17, 2003·World Journal of Gastroenterology : WJG·Yu LiZhi-Nan Chen
Feb 17, 2006·Cancer Biology & Therapy·Zheng ZhangPing Zhu
Mar 17, 2006·Cancer·Maria A Hawkins, Laura A Dawson
Mar 18, 2006·The American Journal of Gastroenterology·Agostino ColliPiergiorgio Duca
May 13, 2006·International Journal of Radiation Oncology, Biology, Physics·Zhi-Nan ChenPing Zhu
Jun 16, 2006·Cancer Biology & Therapy·Qing ZhangZhinan Chen
Dec 6, 2006·International Journal of Radiation Oncology, Biology, Physics·Elvio G RussiUmberto Ricardi
Jan 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jing XuZhi-Nan Chen
May 15, 2008·Journal of the National Cancer Institute·Josep M LlovetUNKNOWN Panel of Experts in HCC-Design Clinical Trials
Feb 24, 2009·Lancet·Jordi Bruix, Josep M Llovet
Jun 25, 2010·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Lorenzo Andreana, Andrew K Burroughs
Jan 6, 2011·Cancer Biotherapy & Radiopharmaceuticals·Lu WuMeng-Chao Wu
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Sep 24, 2011·Seminars in Radiation Oncology·Laura A Dawson
Sep 24, 2011·Seminars in Radiation Oncology·Mary Feng, Edgar Ben-Josef
Oct 14, 2011·The New England Journal of Medicine·Hashem B El-Serag
Oct 18, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Martina Steiner, Dario Neri
Nov 24, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Seanthan SenthilnathanRiad Salem
Citations
Aug 21, 2013·Experimental and Molecular Pathology·Katharina GruppStefan Steurer
Jan 1, 2014·World Journal of Gastroenterology : WJG·Qing HeAn-Ren Kuang
Sep 12, 2014·Journal of the National Cancer Institute·Huijie BianZhi-Nan Chen
Jan 19, 2016·BioMed Research International·Cory D BovenziJoseph M Curry
Nov 28, 2012·Molecular Oncology·Yan ZhangJunnian Zheng
Oct 9, 2014·Journal of Zhejiang University. Science. B·Chai-Hong YeongKwan-Hoong Ng
Nov 27, 2014·Clinical & Experimental Metastasis·Yuan WangHuijie Bian
Aug 14, 2009·Journal of Experimental & Clinical Cancer Research : CR·Ping WuEdward J Mills
Jan 23, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Meng LuHuijie Bian
Mar 14, 2019·Cancer Medicine·Shuling ChenSui Peng
Nov 12, 2016·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Ze-Xin ZhuJi-Wei Huang
Jun 20, 2019·The Journal of Pathology·Yu-Le YongHuijie Bian
Oct 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Wei-Hsiang LinDing-Shinn Chen
Dec 3, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Jun Ma, Jian-Hua Wang
Oct 13, 2017·Physiology·Shiren SunQi Qian
Nov 20, 2013·Experimental and Therapeutic Medicine·Dong DaiXiaoying Ma
Dec 7, 2017·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Lu WuChangqing Su
Nov 8, 2014·Molecular Cancer Therapeutics·Zheng ZhangZhinan Chen
Mar 14, 2020·The Lancet. Gastroenterology & Hepatology·Jun LiFeng Shen