PMID: 8945945Nov 1, 1996Paper

Hepatic capillary pressure is estimated using triple vascular occlusion method in isolated canine liver

The American Journal of Physiology
Toshishige ShibamotoS Koyama

Abstract

We determined whether the triple vascular occlusion pressure (Pto), the equilibration pressure obtained when the hepatic artery, portal, and hepatic veins were occluded simultaneously, represented the capillary pressure (Pc) in isolated bivascularly blood-perfused canine livers. Effects of a bolus injection of histamine (0.1-60 micrograms), norepinephrine (NE; 1-600 micrograms), or acetylcholine (ACh; 0.01-10 micrograms) into the portal vein or the hepatic artery were also studied on vascular resistance distribution using Pto as a measure of Pc. The livers were perfused at constant flow via the portal vein and at constant pressure via the hepatic artery. Pto was compared with Pc measured using the traditional gravimetric method (Pc,i). Pto and Pc,i showed a strong correlation (Pto = -0.02 + 0.98 Pc,i; r = 0.83, P = 0.0018). With comparisons, the intercept was not significantly different from zero, and the slope was not different from 1.00, indicating that Pto accurately represented Pc. The resting postsinusoidal vascular resistance comprised 54% of the total hepatic vascular resistance (Rt). Portal or arterial injection of histamine increased predominantly hepatic venous resistance (Rhv) over portal resistance with liver weight...Continue Reading

Citations

Aug 30, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Chiaki KamikadoShozo Koyama
Sep 20, 2000·American Journal of Physiology. Heart and Circulatory Physiology·C F Rothe, R Maass-Moreno
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·H KjekshusO A Smiseth

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