Hepatic clearance and retention of aluminium: studies in the isolated perfused rat liver

Toxicology Letters
M WilhelmH Idel

Abstract

Aluminium (Al) exposure can result in Al accumulation in the liver and this metal can be toxic to the hepatic tissue at high concentrations. In the present study the model of the isolated perfused rat liver was used to investigate the hepatic handling of Al. Livers from male Wistar rats were perfused in a recirculating system for 240 min. The liver function remained unchanged at perfusate concentrations of Al ranging from 4.9 to 1530.0 micrograms/l. At higher Al levels of 6535.3-16694.9 micrograms/l signs of toxicity towards isolated perfused livers were observed as indicated by an increased release of the enzymes AST and ALT into the perfusate, a pronounced reduction of bile flow rate and a 50% suppression of oxygen consumption. The hepatic Al clearance was low and decreased with increasing concentrations of Al in the perfusate from 4.3 +/- 0.6 microliters/min per g liver at a nominal Al concentration of 9.1 micrograms/l in control perfusate to 0.04 +/- 0.02 microliter/min per g liver at the highest concentration group. There was almost a linear dose dependent retention of Al in the liver with 4.9-635.7 micrograms Al/l perfusate while at higher concentrations Al levels in this organ increased disproportionally. It is concluded...Continue Reading

References

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Citations

Jul 23, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J E Sutherland, J L Greger
Mar 17, 2012·Environmental Toxicology·Punita BhasinD K Dhawan
Apr 16, 2003·International Journal of Experimental Pathology·M G AbubakarG A A Ferns
Jan 7, 2003·Toxicologic Pathology·Christian Grosse-SiestrupDavid A Groneberg
Jun 12, 2009·The Journal of Surgical Research·Gianpiero GravanteAshley R Dennison
Jun 8, 2002·Toxicologic Pathology·David A GronebergAxel Fischer
Apr 22, 2015·Toxicology and Industrial Health·Ben WangYanfei Li
Oct 4, 2020·Environmental Toxicology and Pharmacology·Fatma M El-DemerdashAnsam B Al Mhanna
Oct 19, 2004·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Fatma M El-Demerdash
May 9, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Al-Sayeda A NewairyMokhtar I Yousef

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