PMID: 8938629Oct 1, 1996Paper

Hepatic concentrations of proenkephalin-derived opioids are increased in a rat model of cholestasis

Liver
Nora V BergasaE A Jones

Abstract

The liver of adult rats with cholestasis secondary to bile duct resection has been shown to express the proenkephalin gene and, by immunohistochemical stains, to contain met-enkephalin. To further study hepatic opioids in cholestasis, concentrations of proenkephalin-derived endogenous opioids were measured in a rat model of cholestasis by the use of radioimmunoassays. The specificity of the immunoreactivity detected by the assays was confirmed by high performance liquid chromatography (HPLC). In adult male rats with cholestasis due to BDR, the concentrations of three proenkephalin-derived opioid peptides were increased. Specifically, the mean hepatic concentrations of met-enkephalin, Met-Enk-Arg6-Phe7 and leu-enkephalin were 2.5 (p < 0.005), 2.1 (p < 0.005) and 2.5 (p < 0.01) fold higher than the corresponding mean for controls. These findings provide further independent evidence that opioid peptides accumulate in the liver in a model of cholestasis and are consistent with de novo synthesis of opioid peptides occurring in the cholestatic liver. This phenomenon may have relevance to the altered function of the opioid system in cholestasis and to the role of the liver as a neuroendocrine organ.

References

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Citations

Jun 3, 2009·Journal of Gastroenterology and Hepatology·Negar FaramarziAhmad R Dehpour
Sep 26, 2015·Clinical Medicine : Journal of the Royal College of Physicians of London·Vinod S HegadeDavid E J Jones
Aug 26, 2017·Frontline Gastroenterology·Vinod S HegadeDavid Ej Jones
Aug 2, 2019·Current Gastroenterology Reports·Miriam M Düll, Andreas E Kremer
Apr 4, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Seyedmehdi PayabvashAhmad Reza Dehpour
Jun 13, 2008·Clinical Reviews in Allergy & Immunology·Marco MarzioniAntonio Benedetti
Jul 20, 2011·Seminars in Cutaneous Medicine and Surgery·Nora V Bergasa
Jul 28, 2019·Scientific Reports·Babina SanjelWon-Sik Shim
Jan 30, 2004·Journal of Gastroenterology and Hepatology·Kiarash RiaziAhmad Reza Dehpour
Dec 24, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kendal JensenShannon Glaser
Oct 16, 2010·Journal of Pediatric Gastroenterology and Nutrition·Aglaia ZellosKathleen B Schwarz
Oct 8, 1999·Journal of Pediatric Gastroenterology and Nutrition·B YerushalmiF M Karrer
Feb 2, 2012·European Journal of Gastroenterology & Hepatology·Annarosa FloreaniNora V Bergasa
Dec 15, 2005·Journal of Palliative Medicine·E A Jones, Z Zylicz
Mar 15, 2012·Journal of Gastroenterology and Hepatology·Mohamad H ImamKeith D Lindor
May 3, 2008·Journal of Medical Case Reports·Vincent HoPeter Boyd
Apr 1, 2011·Current Opinion in Gastroenterology·Ronald P J Oude ElferinkUlrich Beuers
Sep 9, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Babina Sanjel, Won-Sik Shim
Apr 9, 2001·Clinics in Liver Disease·E A Fagan

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